Université de Lausanne

Replicating adenoviruses targeting tumours with constitutive activation of the Wnt signalling pathway

Fuerer, Christophe ; Iggo, Richard (Dir.) ; Widmer, François (Codir.)

Thèse de doctorat : Université de Lausanne, 2004.

Activation of the Wnt pathway through mutation of the adenomatous polyposis coli and -catenin genes is a hallmark of colon cancer. These mutations lead to constitutive activation of transcription from promoters containing binding sites for Tcf/LEF transcription factors. Tumour-selective replicating oncolytic viruses are promising agents for cancer therapy. They can in principle spread...