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Université de Neuchâtel

Increasing the size of metalla-assemblies to target the EPR-effect of tumors and solid cancers

Mannancherril, Vidya ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Cancer, a malignant disease, is one of the leading causes of mortality and morbidity among humans. However, selective targeting of cancerous tissue remains challenging. The enhanced permeability and retention effect (EPR-effect), a naturally occurring phenomenon in solid cancerous tissue, is a suitable treatment pathway to selectively target cancerous tissues, whereas healthy tissue remains...

Université de Neuchâtel

Hydrogen-bonded metalla-assemblies

Zhang, Fan ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Hydrogen bonds are the most utilized non-covalent interactions in biological systems, due to their directionality, stability, reversibility and diversity. The weak strength of hydrogen-bond can be modified by combining several hydrogen bonds in the same unit, like in the melamine∙cyanuric/barbituric acid rosette-type system. Arene ruthenium metalla-assemblies have showed a great biological...

Université de Fribourg

Novel iron tweezers complexes for hydrogenation and polymerization of olefins

Mafua, Roger ; Jenny, Titus A. (Dir.)

Thèse de doctorat : Université de Fribourg, 2006 ; no. 1503.

The use of organometallic complexes as catalysts became a very significant topic in the field of material chemistry. However, despite of this development, only few of them contain iron(II), except the tridentate complex diimine pyridine developed by Gibson and Brookhart and employed in the olefin polymerization. Unfortunately, this model suffers by its lack of tolerance towards the minor changes...

Université de Neuchâtel

Conception, synthèse et étude de "tris"-fullérodendrimères et rotaxanes liquides-cristallins

Pieper, Pauline ; Deschenaux, Robert (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2017.

Ce travail de thèse est basé sur l’utilisation de l’auto-assemblage de dendrimères liquides-cristallins pour créer des architectures supramoléculaires complexes contenant des éléments isotropes tels que les [60]fullerène (C60) ou des rotaxanes. Le but a été d’étudier l’influence de l’incorporation de ces éléments isotropes sur la formation et la stabilité des...

Université de Fribourg

Engineering metal oxides for UV-stable perovskite solar cells

Roose, Bart ; Steiner, Ullrich (Dir.)

Thèse de doctorat : Université de Fribourg, 2017 ; no. 2015.

Diese Arbeit untersucht die Anwendung von Metalloxiden als Elektronentransportmaterial in Perowskit-Solarzellen. Die zentrale Forschungsfrage ist, wie Metalloxide die Stabilität von Perowskit-Solarzellen beeinflussen und wie Metalloxide, beispielsweise durch gezielte Dotierung, modifiziert werden können, um die Stabilität von Solarzellen zu verbessern. Die Arbeit beginnt mit vier einleitenden...

Université de Neuchâtel

Calix[n]tetrahydrofuran[4-n]pyrrolidines : optimized synthesis via hydrogenation of calix[n]furan[4-n]pyrroles, conformational study and preliminary work on their transition metal complexes

Maupillier, William ; Neier, Reinhard (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2016.

An hydrogenation method for the reduction of the easy accessible meso-octaalkylporphirinogen (calix[4]pyrrole) has previously been reported in our group. This “standard method” leads to an unsatisfactory conversion to the saturated analogue, calix[4]pyrrolidine (18% yield determined by GC). However using large excess of the catalyst leads to total conversion. In order to study...

Université de Neuchâtel

New approaches for the synthesis of advanced precursors of Rhazinilam analogues

Kholod Zaitseva, Inga ; Neier, Reinhard (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2014.

The purpose of this thesis was to explore different approaches for the synthesis of advanced precursors of rhazinilam analogues. The intramolecular Michael Addition was envisaged in order to obtain the pyrrole or pyrrolinone based analogues. The aim of the first project was to develop a flexible, efficient synthesis towards model systems. N-acylation and N-alkylation of the corresponding...

Université de Neuchâtel

A novel nano-optical sensing approach for real-time amyloid aggregation monitoring

Santi, Sara ; Neier, Reinhard (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2016.

The misfolding and aggregation of amyloid proteins has been associated with incurable diseases such as Alzheimer's or Parkinson's disease. In the specific case of Alzheimer's disease, insoluble mature fibrils formed of amyloid-beta (Aβ) peptide aggregates are one of the gross features detectable in brain of Alzheimer-disease-affected patients. Insoluble mature fibrils were for long time believed...

Université de Neuchâtel

Conception de bisfullérodendrimères liquides-cristallins par la réaction de métathèse croisée d'oléfines

Russo, Virginie ; Deschenaux, Robert (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2016.

Le fil conducteur de cette thèse, a été la conception de bisfullérodendrimères présentant des propriétés liquides-cristallines. En effet, les fullérodendrimères liquides-cristallins sont des sujets d’études très intéressants. En associant le [60]fullerène (C60) avec l’organisation des cristaux-liquides, les possibilités et applications dans le domaine des matériaux...

Université de Neuchâtel

Thiolato-bridged arene ruthenium complexes as anticancer agents

Stíbal, David ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2015.

Cancer is a major cause of morbidity and mortality in today’s world, affecting populations in all countries and all regions. Although no drug or treatment able to cure cancer in all of its forms and variations was found so far, the clinical advancements of 20th and 21st century provided a number of effective drugs for specific types of cancers and had a significant effect...