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Università della Svizzera italiana

Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling

Casalou, Cristina ; Faustino, Alexandra ; Silva, Fernanda ; Ferreira, Inês C. ; Vaqueirinho, Daniela ; Ferreira, Andreia ; Castanheira, Pedro ; Barona, Teresa ; Ramalho, José S. ; Serpa, Jacinta ; Félix, Ana ; Barral, Duarte C.

In: Cancers, 2019, vol. 11, no. 10, p. 1461

Breast cancer is the first cause of cancer-related mortality among women worldwide, according to the most recent estimates. This mortality is mainly caused by the tumors’ ability to form metastases. Cancer cell migration and invasion are essential for metastasis and rely on the interplay between actin cytoskeleton remodeling and cell adhesion. Therefore, understanding the mechanisms by which...

Università della Svizzera italiana

The novel TORC1/2 kinase inhibitor PQR620 has anti-tumor activity in lymphomas as a single agent and in combination with venetoclax

Tarantelli, Chiara ; Gaudio, Eugenio ; Hillmann, Petra ; Spriano, Filippo ; Sartori, Giulio ; Aresu, Luca ; Cascione, Luciano ; Rageot, Denise ; Kwee, Ivo ; Beaufils, Florent ; Zucca, Emanuele ; Stathis, Anastasios ; Wymann, Matthias P. ; Cmiljanovic, Vladimir ; Fabbro, Doriano ; Bertoni, Francesco

In: Cancers, 2019, vol. 11, no. 6, p. 775

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling cascade is an important therapeutic target for lymphomas. Rapamycin-derivates as allosteric mTOR complex 1 (TORC1) inhibitors have shown moderate preclinical and clinical anti-lymphoma activity. Here, we assessed the anti-tumor activity of PQR620, a novel brain penetrant dual TORC1/2 inhibitor, in 56...

Università della Svizzera italiana

Sedentary behaviour in Swiss children and adolescents : disentangling associations with the perceived and objectively measured environment

Bringolf-Isler, Bettina ; De Hoogh, Kees ; Schindler, Christian ; Kayser, Bengt ; Suggs, L. Suzanne ; Dössegger, Alain ; Probst-Hensch, Nicole ; The SOPHYA Study Group

In: International journal of environmental research and public health, 2018, vol. 15, no. 5, p. 918

Identifying correlates of sedentary behaviour across all levels of the ecological model and understanding their interrelations is a promising method to plan effective interventions. The present study examined whether the objectively assessed and the perceived neighbourhood are associated with children’s sedentary behaviour time (SBT). A comprehensive set of factors at different levels of...

Università della Svizzera italiana

The measurements and an elaborated understanding of Chinese eHealth literacy (C-eHEALS) in chronic patients in China

Chang, Angela ; Schulz, Peter J.

In: International journal of environmental research and public health, 2018, vol. 15, no. 7, p. 1553

The rapid rise of Internet-based technologies to disseminate health information and services has been shown to enhance online health information acquisition. A Chinese version of the electronic health literacy scale (C-eHEALS) was developed to measure patients’ combined knowledge and perceived skills at finding and applying electronic health information to health problems. A valid sample...

Università della Svizzera italiana

Mechanical and control design of an industrial exoskeleton for advanced human empowering in heavy parts manipulation tasks

Mauri, Alessandro ; Lettori, Jacopo ; Fusi, Giovanni ; Fausti, Davide ; Mor, Maurizio ; Braghin, Francesco ; Legnani, Giovanni ; Roveda, Loris

In: Robotics, 2019, vol. 8, no. 3, p. 65

Exoskeleton robots are a rising technology in industrial contexts to assist humans in onerous applications. Mechanical and control design solutions are intensively investigated to achieve a high performance human-robot collaboration (e.g., transparency, ergonomics, safety, etc.). However, the most of the investigated solutions involve high-cost hardware, complex design solutions and standard...

Università della Svizzera italiana

The role of smart meters in enabling real-time energy services for households : the Italian case

Pitì, Alessandro ; Verticale, Giacomo ; Rottondi, Cristina ; Capone, Antonio ; Lo Schiavo, Luca

In: Energies, 2017, vol. 10, no. 2, p. 199

The Smart Meter (SM) is an essential tool for successful balancing the demand-offer energy curve. It allows the linking of the consumption and production measurements with the time information and the customer’s identity, enabling the substitution of flat-price billing with smarter solutions, such as Time-of-Use or Real-Time Pricing. In addition to sending data to the energy operators for...

Università della Svizzera italiana

Computational assessment of facial expression production in ASD children

Leo, Marco ; Carcagnì, Pierluigi ; Distante, Cosimo ; Spagnolo, Paolo ; Mazzeo, Pier Luigi ; Rosato, Anna Chiara ; Petrocchi, Serena ; Pellegrino, Chiara ; Levante, Annalisa ; De Lumè, Filomena ; Lecciso, Flavia

In: Sensors, 2018, vol. 18, no. 11, p. 3993

In this paper, a computational approach is proposed and put into practice to assess the capability of children having had diagnosed Autism Spectrum Disorders (ASD) to produce facial expressions. The proposed approach is based on computer vision components working on sequence of images acquired by an off-the-shelf camera in unconstrained conditions. Action unit intensities are estimated by...

Università della Svizzera italiana

Computational analysis of deep visual data for quantifying facial expression production

Leo, Marco ; Carcagnì, Pierluigi ; Distante, Cosimo ; Mazzeo, Pier Luigi ; Spagnolo, Paolo ; Levante, Annalisa ; Petrocchi, Serena ; Lecciso, Flavia

In: Applied sciences, 2019, vol. 9, no. 21, p. 4542

The computational analysis of facial expressions is an emerging research topic that could overcome the limitations of human perception and get quick and objective outcomes in the assessment of neurodevelopmental disorders (e.g., Autism Spectrum Disorders, ASD). Unfortunately, there have been only a few attempts to quantify facial expression production and most of the scientific literature ...

Università della Svizzera italiana

Coating and functionalization strategies for nanogels and nanoparticles for selective drug delivery

Pinelli, Filippo ; Giuseppe Perale ; Filippo Rossi

In: Gels, 2020, vol. 6, no. 1, p. 6

Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be...

Università della Svizzera italiana

Food perceptions and dietary changes for chronic condition management in rural Peru : insights for health promotion

Perez-Leon, Silvana ; Pesantes, M. Amalia ; Aya Pastrana, Nathaly ; Raman, Shivani ; Miranda, Jaime ; Suggs, L. Suzanne

In: Nutrients, 2018, vol. 10, no. 11, p. 1563

Peru is undergoing a nutrition transition and, at the country level, it faces a double burden of disease where several different conditions require dietary changes to maintain a healthy life and prevent complications. Through semistructured interviews in rural Peru with people affected by three infectious and noninfectious chronic conditions (type 2 diabetes, hypertension, and...