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Université de Fribourg

Unveiling the Semimetallic Nature of 1$T$-TiSe$_2$ by Doping its Charge Density Wave

Jaouen, Thomas ; Rumo, Maxime ; Hildebrand, Baptiste ; Mottas, Marie-Laure ; Nicholson, Christopher W. ; Kremer, Geoffroy ; Salzmann, Björn ; Vanini, Fabiano ; Barreteau, C. ; Giannini, E. ; Beck, Hans-Peter ; Aebi, Philipp ; Monney, Claude

The semimetallic or semiconducting nature of the transition metal dichalcogenide 1$T$-TiSe$_2$ remains under debate after many decades mainly due to the fluctuating nature of its 2 x 2 x 2 charge-density-wave (CDW) phase at room- temperature. In this letter, using angle-resolved photoemission spectroscopy, we unambiguously demonstrate that the 1$T$-TiSe$_2$ normal state is semimetallic with ...

Università della Svizzera italiana

Endoplasmic reticulum and lysosomal quality control of four nonsense mutants of iduronate 2-sulfatase linked to Hunter’s syndrome

Marazza, Alessandro ; Galli, Carmela ; Fasana, Elisa ; Sgrignani, Jacopo ; Burda, Patricie ; Enrico M. A. Fassi ; Matthias Baumgartner ; Andrea Cavalli ; Maurizio Molinari

In: DNA and cell biology

Hunter’s syndrome (mucopolysaccharidosis type II) is a rare X-linked lysosomal storage disorder caused by mutations in the iduronate 2-sulfatase (IDS) gene. Motivated by the case of a child affected by this syndrome, we compared the intracellular fate of wild type IDS (IDSWT) and of four nonsense mutations of IDS (IDSL482X, IDSY452X, IDSR443X and IDSW337X) generating progressively shorter ...

Université de Fribourg

An expression atlas of chemosensory ionotropic glutamate receptors identifies a molecular basis of carbonation detection

Sánchez-Alcañiz, Juan Antonio ; Silbering, Ana Florencia ; Croset, Vincent ; Zappia, Giovanna ; Sivasubramaniam, Anantha Krishna ; Abuin, Liliane ; Sahai, Saumya Yashmohini ; Auer, Thomas O. ; Cruchet, Steeve ; Neagu-Maier, G. Larisa ; Sprecher, Simon G. ; Yapici, Nilay ; Benton, Richard

Taste perception is thought to involve the encoding of appetitive and aversive chemical cues in food through a limited number of sensory pathways. Through expression analysis of the complete repertoire of Drosophila Ionotropic Receptors (IRs), a sensory subfamily of ionotropic glutamate receptors, we reveal that the majority of IRs is expressed in diverse peripheral neuron populations across...

Université de Fribourg

Mushroom body-specific profiling of gene expression identifies regulators of long-term memory in Drosophila

Widmer, Yves F. ; Bilican, Adem ; Bruggmann, Rémy ; Sprecher, Simon G.

Memory formation is achieved by genetically tightly controlled molecular pathways that result in a change of synaptic strength and synapse organization. While for short- term memory traces rapidly acting biochemical pathways are in place, the formation of long-lasting memories requires changes in the transcriptional program of a cell. Although many genes involved in learning and memory...

Université de Fribourg

Loss of CaMKI function disrupts salt aversive learning in C. elegans

Lim, Jana P. ; Fehlauer, Holger ; Glauser, Dominique ; Brunet, Anne ; Goodman, Miriam B.

The ability to adapt behavior to environmental fluctuations is critical for survival of organisms ranging from invertebrates to mammals. Caenorhabditis elegans can learn to avoid sodium chloride when it is paired with starvation. This behavior is likely advantageous to avoid areas without food. While some genes have been implicated in this salt aversive learning behavior, critical genetic...

Université de Fribourg

Organization of the Drosophila larval visual circuit

Larderet, Ivan ; Fritsch, Pauline ; Gendre, Nanae ; Maier, Larisa ; Fetter, Rick D. ; Schneider-Mizell, Casey ; Truman, James ; Zlatic, Marta ; Cardona, Albert ; Sprecher, Simon

Visual systems transduce, process and transmit light-dependent environmental cues. Computation of visual features depends on the types of photoreceptor neurons (PR) present, the organization of the eye and the wiring of the underlying neural circuit. Here, we describe the circuit architecture of the visual system of Drosophila larvae by mapping the synaptic wiring diagram and...

Université de Fribourg

Reproducing Botryosphaeria dieback foliar symptoms in a simple model system

Reis, Pedro ; Magnin-Robert, Maryline ; Nascimento, Teresa ; Spagnolo, Alessandro ; Abou-Mansour, Eliane ; Fioretti, Cristina ; Clément, Christophe ; Rego, Cecilia ; Fontaine, Florence

In: Plant Disease

Botryosphaeria dieback is a grapevine trunk disease with a worldwide distribution and associated with Diplodia seriata and Neofusicoccum parvum among several other Botryosphaeriaceae species. The aforementioned xylem-inhabiting fungi cause wood lesions, leaf and berry symptoms and eventually lead to the death of the plant. The aim of this work was to develop a simple model system to reproduce the...

Université de Fribourg

Changes in plant metabolism and accumulation of fungal metabolites in response to Esca proper and apoplexy expression in the whole grapevine

Magnin-Robert, Maryline ; Spagnolo, Alessandro ; Boulanger, Anna ; Joyeux, Cécile ; Clément, Christophe ; Abou-Mansour, Eliane ; Fontaine, Florence

In: Phytopathology

Trunk diseases have become among the most important grapevine diseases worldwide. They are caused by fungal pathogens that attack the permanent woody structure of the vines and cause various symptoms in woody and annual organs. This study examined modifications of plant responses in green stem, cordon and trunk of grapevines expressing Esca proper (E) or apoplexy (A) event, which are the most...