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Université de Fribourg

The influence of gender and anthropometry on haemodynamic status at rest and in response to graded incremental head-up tilt in young, healthy adults

Sarafian, Delphine ; Miles-Chan, Jennifer L.

In: Frontiers in Physiology, 2017, vol. 7, p. -

The body's ability to rapidly and appropriately regulate blood pressure in response to changing physiological demand is a key feature of a healthy cardiovascular system. Passively tilting the body, thereby changing central blood volume, is a well-recognized and controlled method of evaluating this ability. However, such studies usually involve single tilt angles, or intermittent tilting...

Université de Fribourg

Energy cost of standing in a multi-ethnic cohort: are energy-savers a minority or the majority?

Monnard, Cathríona R. ; Miles-Chan, Jennifer L.

In: PLOS ONE, 2017, vol. 12, no. 1, p. e0169478

The disease risks associated with sedentary behavior are now firmly established, and consequently there is much interest in methods of increasing low-intensity physical activity. In this context, it is a widely held belief that altering posture allocation can modify energy expenditure (EE) to impact upon body weight regulation and health. However, we recently showed the existence of two...

Haute Ecole pédagogique Fribourg

La pensée critique et la pensée créative comme composantes essentielles de la pensée mathématique

Roy, Patrick ; Schubnel, Yves

In: Bulletin du Centre de recherche sur l’enseignement et l’apprentissage des sciences (CREAS), 2017, no. 3, p. 20-28

Université de Fribourg

Glucagon-like peptide-1 and its analogues act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight

Anderberg, Rozita H ; Richard, Jennifer E ; Eerola, Kim ; Ferreras, Lorena Lopez ; Nordbeck, Elin Banke ; Hansson, Caroline ; Nissbrandt, Hans ; Berqquist, Filip ; Gribble, Fiona M ; Reimann, Frank ; Wernstedt-Asterholm, Ingrid ; Lamy, Christophe M. ; Skibicka, Karolina P

In: Diabetes, 2017, p. -

Glucagon-like peptide-1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as anti-obesity strategies. Surprisingly whether they interact in order to regulate energy balance is poorly understood. Here we investigated mechanisms by which GLP-1 and serotonin interact at the level of the CNS. Serotonin depletion impaired the ability of...

Université de Fribourg

Interactions of human microglia cells with Japanese encephalitis virus

Lannes, Nils ; Neuhaus, Viviane ; Scolari, Brigitte ; Kharoubi-Hess, Solange ; Walch, Michael ; Summerfield, Artur ; Filgueira, Luis

In: Virology Journal, 2017, vol. 14, p. 8

Japanese encephalitis virus (JEV) is a neurotropic flavivirus causing mortality and morbidity in humans. Severe Japanese encephalitis cases display strong inflammatory responses in the central nervous system and an accumulation of viral particles in specific brain regions. Microglia cells are the unique brain-resident immune cell population with potent migratory functions and have been...

Université de Fribourg

The interaction between the vastus medialis and vastus intermedius and its influence on the extensor apparatus of the knee joint

Grob, Karl ; Manestar, Mirjana ; Filgueira, Luis ; Kuster, Markus S. ; Gilbey, Helen ; Ackland, Timothy

In: Knee Surgery, Sports Traumatology, Arthroscopy, 2017, p. 1–12

Although the vastus medialis (VM) is closely associated with the vastus intermedius (VI), there is a lack of data regarding their functional relationship. The purpose of this study was to investigate the anatomical interaction between the VM and VI with regard to their origins, insertions, innervation and function within the extensor apparatus of the knee joint.Methods: Eighteen human...

Université de Fribourg

Collateral fattening: when a deficit in lean body mass drives overeating

Dulloo, Abdul G.

In: Obesity, 2017, vol. 25, no. 2, p. 277–279

In his last review entitled “Some Adventures in Body Composition,” Gilbert Forbes reminded us that “lean body mass and body fat are in a sense companions.” To what extent the lean body mass (or fat-free mass) component in this companionship impacts on energy intake is rarely a topic for discussion, amid a dominant adipocentric view of appetite control. Yet an analysis of the few human...

Université de Fribourg

Isometric thermogenesis at rest and during movement: a neglected variable in energy expenditure and obesity predisposition

Dulloo, Abdul G. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2017, vol. 18, no. S1, p. 56–64

Isometric thermogenesis as applied to human energy expenditure refers to heat production resulting from increased muscle tension. While most physical activities consist of both dynamic and static (isometric) muscle actions, the isometric component is very often essential for the optimal performance of dynamic work given its role in coordinating posture during standing, walking and most...

Université de Fribourg

Parvalbumin-neurons of the ventrolateral hypothalamic parvafox nucleus receive a glycinergic input: a gene-microarray study

Szabolcsi, Viktoria ; Albisetti, Gioele W. ; Celio, Marco R.

In: Frontiers in Molecular Neuroscience, 2017, vol. 10, p. -

The ventrolateral hypothalamic parvafox (formerly called PV1-Foxb1) nucleus is an anatomical entity of recent discovery and unknown function. With a view to gaining an insight into its putative functional role(s), we conducted a gene-microarray analysis and, armed with the forthcoming data, controlled the results with the Allen databases and the murine BrainStars (B*) database. The parvafox...