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Dynamic laser speckle imaging of cerebral blood flow

Zakharov, Pavel ; Völker, A. C. ; Wyss, M. T. ; Haiss, F. ; Calcinaghi, N. ; Zunzunegui, C. ; Buck, Alfred ; Scheffold, Frank ; Weber, Bruno

In: Optics Express, 2009, vol. 17, no. 16, p. 13904-13917

Laser speckle imaging (LSI) based on the speckle contrast analysis is a simple and robust technique for imaging of heterogeneous dynamics. LSI finds frequent application for dynamical mapping of cerebral blood flow, as it features high spatial and temporal resolution. However, the quantitative interpretation of the acquired data is not straightforward for the common case of a speckle field formed...