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Université de Fribourg

Rapid and sensitive quantification of cell-associated multi-walled carbon nanotubes

Steinmetz, Lukas ; Bourquin, Joel ; Barosova, Hana ; Haeni, Laetitia ; Caldwell, Jessica ; Milosevic, Ana ; Geers, Christoph ; Bonmarin, Mathias ; Taladriz-Blanco, Patricia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2020, vol. 12, no. 33, p. 17362–17372

Evaluating nanomaterial uptake and association by cells is relevant for in vitro studies related to safe-by-design approaches, nanomedicine or applications in photothermal therapy. However, standard analytical techniques are time-consuming, involve complex sample preparation or include labelling of the investigated sample system with e.g. fluorescent dyes. Here, we explore lock-in...

Université de Fribourg

Tailor-made functional polymers for energy storage and environmental applications

Coskun, Ali

In: CHIMIA International Journal for Chemistry, 2020, vol. 74, no. 9, p. 667–673

CO2 emissions into the atmosphere account for the majority of environmental challenges and its global impact in the form of climate change is well-documented. Accordingly, the development of new materials approaches to capture and convert CO2 into value-added products is essential. Whereas the increased availability of renewable energy is curbing our reliance on fossil fuels and decreasing...

Université de Fribourg

Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

Sovari, Sara Nasiri ; Vojnovic, Sandra ; Bogojevic, Sanja Skaro ; Crochet, Aurelien ; Pavic, Aleksandar ; Nikodinovic-Runic, Jasmina ; Zobi, Fabio

In: European Journal of Medicinal Chemistry, 2020, vol. 205, p. 112533

We have prepared a series of ten 3-arylcoumarin molecules, their respective fac- [Re(CO)3(bpy)L]+ and fac-[Re(CO)3(L⁀L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) > 150 μM, when coordinated to the fac-[Re(CO)3]+ core,...

Université de Fribourg

Monolithic resorcinol–formaldehyde alcogels and their corresponding nitrogen-doped activated carbons

Civioc, Romain ; Lattuada, Marco ; Koebel, Matthias M. ; Galmarini, Sandra

In: Journal of Sol-Gel Science and Technology, 2020, vol. 95, no. 3, p. 719–732

Here we report the adaptation of formaldehyde crosslinked phenolic resin-based aerogel and xerogel synthesis to ethanol-based solvent systems. Three specific formulations, namely one resorcinol–formaldehyde (RF) and two resorcinol– melamine–formaldehyde (RMF) systems were studied. As-prepared resins were characterized in terms of envelope and skeletal density. Furthermore, resin samples ...

Université de Fribourg

Handling (nano)silver as antimicrobial agent: therapeutic window, dissolution dynamics, detection methods and molecular interactions

Abram, Sarah‐Luise ; Fromm, Katharina M.

In: Chemistry – A European Journal, 2020, vol. 26, no. 48, p. 10948–10971

Silver is an antimicrobial agent well known since antiquity. With the emergence of multiresistant bacteria, it has come back into the focus of research, and ionic as well as nano‐sized silver have been studied in vitro and in vivo. The results are controversial, silver being discussed as the “silver bullet” or a “wolf in sheep's clothing”. A thorough search of literature from...

Université de Fribourg

Bimetallic salen-based compounds and their potential applications

Finelli, Alba ; Abram, Sarah-Luise ; Hérault, Nelly ; Crochet, Aurélien ; Fromm, Katharina M.

In: Crystal Growth & Design, 2020, vol. 20, no. 8, p. 4945–4958

The new bimetallic coordination compounds [LNiAg(NO3)], [LCuMn(NO3)2], [LCuCu(NO3)2], [LCuZn(NO3)2], and [{LCuBi(NO3)3}(ACN)] have been synthesized from a salen-type ligand L containing two distinct coordination sites to accommodate (different) metal ions M1 and M2. In the solid state, the formation of 1:1 compounds (LCu:M2) is always observed, but interactions between the compounds lead to ...

Université de Fribourg

In situ deprotection of polymeric binders for solution‐processible sulfide‐based all‐solid‐state batteries

Lee, Jieun ; Lee, Kyulin ; Lee, Taegeun ; Kim, Hyuntae ; Kim, Kyungsu ; Cho, Woosuk ; Coskun, Ali ; Char, Kookheon ; Choi, Jang Wook

In: Advanced Materials, 2020, p. 2001702

Sulfide‐based all‐solid‐state batteries (ASSBs) have been featured as promising alternatives to the current lithium‐ion batteries (LIBs) mainly owing to their superior safety. Nevertheless, a solution‐based scalable manufacturing scheme has not yet been established because of the incompatible polarity of the binder, solvent, and sulfide electrolyte during slurry preparation. This...

Université de Fribourg

Resonance raman optical activity shows unusual structural sensitivity for systems in resonance with multiple excited states: vitamin B12 case

Machalska, Ewa ; Zajac, Grzegorz ; Gruca, Anna ; Zobi, Fabio ; Baranska, Malgorzata ; Kaczor, Agnieszka

In: The Journal of Physical Chemistry Letters, 2020, vol. 11, no. 13, p. 5037–5043

In this work, cobalamins with different upper axial substituents and a cobalamin derivative with a ring modification were studied using chiroptical spectroscopies, in particular resonance Raman optical activity (RROA), to shed light on the influence of structural modifications on RROA spectra in these strongly chiral systems in resonance with multiple excited states at 532 nm excitation. We...

Université de Fribourg

Nanostructure generation during milk digestion in presence of a cell culture model simulating the small intestine

Hempt, Claudia ; Gontsarik, Mark ; Buerki-Thurnherr, Tina ; Hirsch, Cordula ; Salentinig, Stefan

In: Journal of Colloid and Interface Science, 2020, vol. 574, p. 430–440

Hypothesis: The development of advanced oral delivery systems for bioactive compounds requires the fundamental understanding of the digestion process within the gastrointestinal tract. Towards this goal, dynamic invitro digestion models, capable of characterising the molecular as well as colloidal aspects of food, together with their biological interactions with relevant invitro cell culture...

Université de Fribourg

Strong, machinable, and insulating chitosan–urea aerogels: toward ambient pressure drying of biopolymer aerogel monoliths

Guerrero-Alburquerque, Natalia ; Zhao, Shanyu ; Adilien, Nour ; Koebel, Matthias M. ; Lattuada, Marco ; Malfait, Wim J.

In: ACS Applied Materials & Interfaces, 2020, vol. 12, no. 19, p. 22037–22049

Biopolymer aerogels are an emerging class of materials with potential applications in drug delivery, thermal insulation, separation, and filtration. Chitosan is of particular interest as a sustainable, biocompatible, and abundant raw material. Here, we present urea-modified chitosan aerogels with a high surface area and excellent thermal and mechanical properties. The irreversible gelation of...