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Université de Fribourg

Proline as a charge stabilizing amino acid in peptide radical cations

Monney, Nicolas P.-A. ; Bally, Thomas ; Giese, Bernd

In: Journal of Physical Organic Chemistry, 2015, vol. 28, no. 5, p. 347–353

Long distance electron transfer in proteins requires relay stations that can be transitorily oxidized or reduced. Although individual prolines cannot assume this function, because of their high ionization energy, it has been shown that polyprolines have the ability to transfer charges. In order to determine the role of the proline in the hole distribution and transport within a PheProPhe...

Université de Fribourg

Bioinorganic chemistry of silver: its interactions with amino acids and peptides

Fromm, Katharina M.

In: CHIMIA International Journal for Chemistry, 2013, vol. 67, no. 12, p. 851–854

Silver and its compounds have been used for centuries for e.g. water storage, burn wounds or as eye ointment. Almost forgotten after the discovery of antibiotics, silver chemistry has had a revival over the past years as a means to combat multi-resistant bacteria. Although the details of its mechanism of action are still unknown, silver seems to be efficient as it interacts with many biomolecular...

Université de Fribourg

Silver nanoparticle formation in different sizes induced by peptides identified within split-and-mix libraries

Belser, Kirsten ; Slenters, Tünde Vig ; Pfumbidzai, Conelious ; Upert, Grégory ; Mirolo, Laurent ; Fromm, Katharina M. ; Wennemers, Helma

In: Angewandte Chemie International Edition, 2009, vol. 48, no. 20, p. 3661-3664

Split-and-mix libraries are an excellent tool for the identification of peptides that induce the formation of Ag nanoparticles in the presence of either light or sodium ascorbate to reduce Ag+ ions. Structurally diverse peptides were detected in colorimetric on-bead screenings that generate Ag nanoparticles of different sizes, as confirmed by SEM and X-ray powder diffraction studies