Université de Fribourg

How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations

Rehrauer, Hubert ; Wu, Licun ; Blum, Walter ; Pecze, Lazslo ; Henzi, Thomas ; Serre-Beinier, Véronique ; Aquino, Catherine ; Vrugt, Bart ; Perrot, Marc de ; Schwaller, Beat ; Felley-Bosco, Emanuela

In: Oncogene, 2018, vol. 37, no. 20, p. 2645–2659

Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with...

Université de Fribourg

LIN-39 and the EGFR/RAS/MAPK pathway regulate C. elegans vulval morphogenesis via the VAB-23 zinc finger protein

Pellegrino, Mark W. ; Farooqui, Sarfarazhussain ; Fröhli, Erika ; Rehrauer, Hubert ; Kaeser-Pebernard, Stéphanie ; Müller, Fritz ; Gasser, Robin B. ; Hajnal, Alex

In: Development, 2011, vol. 138, no. 4649-4660, p. -

Morphogenesis represents a phase of development during which cell fates are executed. The conserved hox genes are key cell fate determinants during metazoan development, but their role in controlling organ morphogenesis is less understood. Here, we show that the C. elegans hox gene lin-39 regulates epidermal morphogenesis via its novel target, the essential zinc finger protein VAB-23. During the...