Université de Fribourg

Review of emerging japanese encephalitis virus: new aspects and concepts about entry into the brain and inter-cellular spreading

Filgueira, Luis ; Lannes, Nils

In: Pathogens, 2019, vol. 8, no. 3, p. 111

Japanese encephalitis virus (JEV) is an emerging flavivirus of the Asia-Pacific region. More than two billion people live in endemic or epidemic areas and are at risk of infection. Recently, the first autochthonous human case was recorded in Africa, and infected birds have been found in Europe. JEV may spread even further to other continents. The first section of this review covers...

Université de Fribourg

CX 3 CR1-CX 3 CL1-dependent cell-to-cell Japanese encephalitis virus transmission by human microglial cells

Lannes, Nils ; Garcia-Nicolàs, Obdullio ; Démoulins, Thomas ; Summerfield, Artur ; Filgueira, Luis

In: Scientific Reports, 2019, vol. 9, no. 1, p. 4833

The neurotropic Japanese encephalitis virus (JEV) is responsible for Japanese encephalitis, an uncontrolled inflammatory disease of the central nervous system. Microglia cells are the unique innate immune cell type populating the brain that cross- communicate with neurons via the CX3CR1-CX3CL1 axis. However, microglia may serve as a viral reservoir for JEV. Human microglia are able to transmit...

Université de Fribourg

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Lannes, Nils ; Eppler, Elisabeth ; Etemad, Samar ; Yotovski, Peter ; Filgueira, Luis

In: Oncotarget, 2017, vol. 8, no. 69, p. 114393–114413

Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the...

Université de Fribourg

Silver-nanoparticles increase bactericidal activity and radical oxygen responses against bacterial pathogens in human osteoclasts

Aurore, Valerie ; Caldana, Fabienne ; Blanchard, Marianne ; Kharoubi Hess, Solange ; Lannes, Nils ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: Nanomedicine: Nanotechnology, Biology and Medicine, 2018, vol. 14, no. 2, p. 601–607

Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its...

Université de Fribourg

Regulation of inflammation in Japanese encephalitis

Lannes, Nils ; Summerfield, Artur ; Filgueira, Luis

In: Journal of Neuroinflammation, 2017, vol. 14, p. 158

Uncontrolled inflammatory response of the central nervous system is a hallmark of severe Japanese encephalitis (JE). Although inflammation is necessary to mount an efficient immune response against virus infections, exacerbated inflammatory response is often detrimental. In this context, cells of the monocytic lineage appear to be important forces driving JE pathogenesis.

Université de Fribourg

Interactions of human microglia cells with Japanese encephalitis virus

Lannes, Nils ; Neuhaus, Viviane ; Scolari, Brigitte ; Kharoubi-Hess, Solange ; Walch, Michael ; Summerfield, Artur ; Filgueira, Luis

In: Virology Journal, 2017, vol. 14, p. 8

Japanese encephalitis virus (JEV) is a neurotropic flavivirus causing mortality and morbidity in humans. Severe Japanese encephalitis cases display strong inflammatory responses in the central nervous system and an accumulation of viral particles in specific brain regions. Microglia cells are the unique brain-resident immune cell population with potent migratory functions and have been...