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    Université de Neuchâtel

    Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for photosensitizers in photodynamic therapy

    Berger, Yann ; Ingrassia, Laurent ; Neier, Reinhard ; Juillerat-Jeanneret, Lucienne

    In: Bioorganic & Medicinal Chemistry, 2003, vol. 11, no. 7, p. 1343-1351

    N-terminal-blocked and N-terminal-free pseudotripeptide Gly-Gly and Gly-Pro derivatives of 5-aminolevulinic acid (ALA) esters were synthesized as potential specific substrates for cellular peptidases and precursors for the production of the photosensitizer protoporphyrin IX (PpIX). These precursors were evaluated using human cell lines of either carcinoma or endothelial origin. N-blocked or...