Université de Neuchâtel

Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

Mattsson, Johan ; Govindaswamy, Padavattan ; Renfrew, Anna K. ; Dyson, Paul J. ; Štěpnička, Petr ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 15, p. 4350–4357

The cytotoxicities of a new series of cationic metallarectangles have been established in the A2780 ovarian cancer cell line. Interestingly, the large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC50 ≤ 6 μM) than the 4,4-bipyridine analogues (IC50 ≥ 30 μM), thus suggesting a correlation between cytotoxicity and the size...

Université de Neuchâtel

Di-μ-chlorido-bis[chlorido(η5-pentamethylcyclopentadienyl)rhodium(III)] chloroform trisolvate

Govindaswamy, Padavattan ; Süss-Fink, Georg ; Therrien, Bruno

In: Acta Crystallographica Section E, 2007, vol. 63, no. 4, p. m931-m932

In the title dinuclear rhodium complex, [Rh2 (C10H15)2Cl4]•3CHCl3, there are two independent centrosymmetric dinuclear complexes per unit cell.

Université de Neuchâtel

Encapsulation of Triphenylene Derivatives in the Hexanuclear Arene Ruthenium Metallo-Prismatic Cage [Ru6 (p-PriC6H4Me)6(tpt)2 (dhbq)3]6+ (tpt = 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine, dhbq = 2,5-dihydroxy-1,4-benzoquinonato)

Govindaswamy, Padavattan ; Furrer, Julien ; Süss-Fink, Georg ; Therrien, Bruno

In: Zeitschrift für anorganische und allgemeine Chemie, 2008, vol. 634, no. 8, p. 1349-1352

A large cationic triangular metallo-prism, [Ru6(p-PriC6H4Me)6 (tpt)2 (dhbq)3]6+ (1)6+, incorporating p-cymene ruthenium building blocks, bridged by 2,5-dihydroxy-1,4-benzoquinonato (dhbq) ligands, and connected by two 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine (tpt) subunits, allows the permanent...

Université de Neuchâtel

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

Schmitt, Frédéric ; Govindaswamy, Padavattan ; Zava, Olivier ; Süss-Fink, Georg ; Juillerat-Jeanneret, Lucienne ; Therrien, Bruno

In: Journal of Biological Inorganic Chemistry, 2009, vol. 14, no. 1, p. 101-109

Mononuclear 5-(4-pyridyl)-10,15,20-triphenylporphyrin and 5-(3-pyridyl)-10,15,20-triphenylporphyrin as well as tetranuclear 5,10,15,20-tetra(4-pyridyl)porphyrin (tetra-4-pp) and 5,10,15,20-tetra(3-pyridyl)porphyrin) (tetra-3-pp) arene ruthenium(II) derivatives (arene is C6H5Me or p-PriC6H4Me) were prepared and evaluated as potential...

Université de Neuchâtel

Chiral or not chiral? A case study of the hexanuclear metalloprisms [Cp*6M6 (µ3-tpt-κN)2(µ-C2O4-κO)3]6+ (M = Rh, Ir, tpt = 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine)

Govindaswamy, Padavattan ; Linder, David ; Lacour, Jerôme ; Süss-Fink, Georg ; Therrien, Bruno

In: Dalton Transactions, 2007, p. 4457-4463

Cationic hexarhodium and hexairidium complexes with a trigonal prismatic architecture have been synthesised in good yield by self-assembly of the dinuclear oxalato-bridged complexes [Cp*2M2 (µ-C2O4-κO)Cl2] (M = Rh; 1: Ir; 2) with 2,4,6-tri(pyridine-4-yl)-1,3,5-triazine (tpt) in the presence of...

Université de Neuchâtel

Self-assembled hexanuclear arene ruthenium metallo-prisms with unexpected double helical chirality

Govindaswamy, Padavattan ; Linder, David ; Lacour, Jerôme ; Süss-Fink, Georg ; Therrien, Bruno

In: Chemical Communications (ChemCom), 2006, p. 4691-4693

Self-assembly of 2,4,6-tripyridyl-1,3,5-triazine (tpt) subunits with arene ruthenium building blocks and oxalato bridges affords cationic triangular metallo-prisms of the type [Ru6 (arene) 6 (tpt)2 (C2O4)3]6+ (arene = C6Me6 and p-PriC6H4Me); the...

Université de Neuchâtel

Mono and dinuclear rhodium, iridium and ruthenium complexes containing chelating 2,2′-bipyrimidine ligands: Synthesis, molecular structure, electrochemistry and catalytic properties

Govindaswamy, Padavattan ; Canivet, Jérôme ; Therrien, Bruno ; Süss-Fink, Georg ; Štěpnička, Petr ; Ludvík, Jiří

In: Journal of Organometallic Chemistry, 2007, vol. 692, no. 17, p. 3664-3675

The mononuclear cations [(η5-C5Me5)RhCl(bpym)]+ (1), [(η5-C5Me5)IrCl(bpym)]+ (2), [(η6-p-PriC6H4Me)RuCl(bpym)]+ (3) and [(η6-C6Me6)RuCl(bpym)]+ (4) as well as the dinuclear dications...

Université de Neuchâtel

Mono and dinuclear iridium, rhodium and ruthenium complexes containing chelating carboxylato pyrazine ligands: Synthesis, molecular structure and electrochemistry

Govindaswamy, Padavattan ; Therrien, Bruno ; Süss-Fink, Georg ; Štěpnička, Petr ; Ludvík, Jiří

In: Journal of Organometallic Chemistry, 2007, vol. 692, no. 8, p. 1661-1671

The mononuclear complexes [(η5-C5Me5)IrCl(L1)] (1), [(η5-C5Me5)RhCl(L1)] (2), [(η6-p-PriC6H4Me)RuCl(L1)] (3) and [(η6-C6Me6)RuCl(L1)] (4) have been synthesised from...