Université de Fribourg

Nanostructure generation during milk digestion in presence of a cell culture model simulating the small intestine

Hempt, Claudia ; Gontsarik, Mark ; Buerki-Thurnherr, Tina ; Hirsch, Cordula ; Salentinig, Stefan

In: Journal of Colloid and Interface Science, 2020, vol. 574, p. 430–440

Hypothesis: The development of advanced oral delivery systems for bioactive compounds requires the fundamental understanding of the digestion process within the gastrointestinal tract. Towards this goal, dynamic invitro digestion models, capable of characterising the molecular as well as colloidal aspects of food, together with their biological interactions with relevant invitro cell culture...

Université de Fribourg

Internal lamellar and inverse hexagonal liquid crystalline phases during the digestion of krill and astaxanthin oil-in-water emulsions

Yaghmur, Anan ; Lotfi, Saleh ; Ariabod, Sarah Atoussa ; Bor, Gizem ; Gontsarik, Mark ; Salentinig, Stefan

In: Frontiers in Bioengineering and Biotechnology, 2019, vol. 7, p. -

Krill oil represents an important alternative natural source of omega-3 (ω-3) polyunsaturated fatty acids (PUFAs). Considering the beneficial health effects of these essential fatty acids, particularly in various disorders including cancer, cardiovascular, and inflammation diseases, it is of paramount importance to gain insight into the digestibility of krill oil. In this work, we study the...

Université de Fribourg

pH-responsive nano-self-assemblies of the anticancer drug 2-hydroxyoleic acid

Prajapati, Rama ; Gontsarik, Mark ; Yaghmur, Anan ; Salentinig, Stefan

In: Langmuir, 2019, vol. 35, no. 24, p. 7954–7961

pH-responsive lipid nanocarriers have the potential to selectively target the acidic extracellular pH environment of cancer tissues and may further improve the efficacy of chemotherapeutics by minimizing their toxic side-effects. Here, we present the design and characterization of pH-sensitive nano-self-assemblies of the poorly water-soluble anticancer drug 2-hydroxyoleic acid (2OHOA) with...

Université de Fribourg

Multifunctional nano‐biointerfaces: cytocompatible antimicrobial nanocarriers from stabilizer‐free cubosomes

Zabara, Mahsa ; Senturk, Berna ; Gontsarik, Mark ; Ren, Qun ; Rottmar, Markus ; Maniura-Weber, Katharina ; Mezzenga, Raffaele ; Bolisetty, Sreenath ; Salentinig, Stefan

In: Advanced Functional Materials, 2019, p. 1904007

The rational design of alternative antimicrobial materials with reduced toxicity toward mammalian cells is highly desired due to the growing occurrence of bacteria resistant to conventional antibiotics. A promising approach is the design of lipid‐based antimicrobial nanocarriers. However, most of the commonly used polymer‐stabilized nanocarriers are cytotoxic. Herein, the design of a...