Université de Fribourg

pH-responsive nano-self-assemblies of the anticancer drug 2-hydroxyoleic acid

Prajapati, Rama ; Gontsarik, Mark ; Yaghmur, Anan ; Salentinig, Stefan

In: Langmuir, 2019, vol. 35, no. 24, p. 7954–7961

pH-responsive lipid nanocarriers have the potential to selectively target the acidic extracellular pH environment of cancer tissues and may further improve the efficacy of chemotherapeutics by minimizing their toxic side-effects. Here, we present the design and characterization of pH-sensitive nano-self-assemblies of the poorly water-soluble anticancer drug 2-hydroxyoleic acid (2OHOA) with...

Université de Fribourg

Multifunctional nano‐biointerfaces: cytocompatible antimicrobial nanocarriers from stabilizer‐free cubosomes

Zabara, Mahsa ; Senturk, Berna ; Gontsarik, Mark ; Ren, Qun ; Rottmar, Markus ; Maniura-Weber, Katharina ; Mezzenga, Raffaele ; Bolisetty, Sreenath ; Salentinig, Stefan

In: Advanced Functional Materials, 2019, p. 1904007

The rational design of alternative antimicrobial materials with reduced toxicity toward mammalian cells is highly desired due to the growing occurrence of bacteria resistant to conventional antibiotics. A promising approach is the design of lipid‐based antimicrobial nanocarriers. However, most of the commonly used polymer‐stabilized nanocarriers are cytotoxic. Herein, the design of a...