Université de Fribourg

Dedicated photoreceptor pathways in Drosophila larvae mediate navigation by processing either spatial or temporal cues

Humberg, Tim-Henning ; Bruegger, Pascal ; Afonso, Bruno ; Zlatic, Marta ; Truman, James W. ; Gershow, Marc ; Samuel, Aravinthan ; Sprecher, Simon G.

In: Nature Communications, 2018, vol. 9, no. 1, p. 1260

To integrate changing environmental cues with high spatial and temporal resolution is critical for animals to orient themselves. Drosophila larvae show an effective motor program to navigate away from light sources. How the larval visual circuit processes light stimuli to control navigational decision remains unknown. The larval visual system is composed of two sensory input channels,...

Université de Fribourg

NONO couples the circadian clock to the cell cycle

Kowalska, Elzbieta ; Ripperger, Juergen A. ; Hoegger, Dominik C. ; Bruegger, Pascal ; Buch, Thorsten ; Birchler, Thomas ; Mueller, Anke ; Albrecht, Urs ; Contaldo, Claudio ; Brown, Steven A.

In: Proceedings of the National Academy of Sciences - PNAS, 2013, vol. 110, no. 5, p. 1592–1599

Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully understood. Previously we identified the multifunctional nuclear protein NONO as a partner of circadian PERIOD (PER) proteins. Here we show that it also conveys circadian gating to the cell cycle, a connection surprisingly important for wound...

Université de Fribourg

uMove : a wholistic framework to design and implement ubiquitous computing systems supporting user's activity and situation

Bruegger, Pascal ; Hirsbrunner, Beat (Dir.)

Thèse de doctorat : Université de Fribourg, 2011.

This thesis presents a framework that offers tools for the design and the implementation of Ubiquitous computing systems supporting user motions, activities and situations. With the rapid development of context-aware mobile computing and sensor-based interaction, many new challenges come up, three of which are particularly addressed in this thesis. The first is the need for wholistic tools to...