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Alpha-helical folding of SilE models upon Ag(His)(Met) motif formation

Chabert, Valentin ; Hologne, Maggy ; Sénèque, Olivier ; Walker, Olivier ; Fromm, Katharina M.

In: Chemical Communications, 2018, vol. 54, no. 74, p. 10419–10422

The SilE protein is suspected to have a prominent role in Ag+ detoxification of silver resistant bacteria. Using model peptides, we elucidated both qualitative and quantitative aspects of the Ag+-induced α-helical structuring role of His- and Met-rich sequences of SilE, improving our understanding of its function within the Sil system.