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    2 Ergebnisse 1
    Université de Fribourg

    Effects of the poly(ADP-ribose) polymerase inhibitor olaparib in cerulein-induced pancreatitis

    Ahmad, Akbar ; Haas De Mello, Aline ; Szczesny, Bartosz ; Törö, Gábor ; Marcatti, Michela ; Druzhyna, Nadiya ; Liaudet, Lucas ; Tarantini, Stefano ; Salomao, Reinaldo ; Garcia Soriano, Francisco ; Szabo, Csaba

    In: Shock, 2020, vol. 53, no. 5, p. 653–665

    Objective: Activation of the constitutive nuclear and mitochondrial enzyme poly (ADP- ribose) polymerase (PARP) has been implicated in the pathogenesis of cell dysfunction, inflammation, and organ failure in various forms of critical illness. The objective of our study was to evaluate the efficacy and safety of the clinically approved PARP inhibitor olaparib in an experimental model of...

    Université de Fribourg

    The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis

    Ahmad, Akbar ; Vieira, Juliana de Camargo ; Mello, Aline Haas de ; Lima, Thais Martins de ; Ariga, Suely Kubo ; Barbeiro, Denise Frediani ; Barbeiro, Hermes Vieira ; Szczesny, Bartosz ; Törö, Gábor ; Druzhyna, Nadiya ; B.Randi, Elisa ; Marcatti, Michela ; Toliver-Kinsky, Tracy ; Kiss, András ; Liaudet, Lucas ; Salomao, Reinaldo ; Soriano, Francisco Garcia ; Szabo, Csaba

    In: Pharmacological Research, 2019, vol. 145, p. 104263

    Poly(ADP-ribose) polymerase (PARP) is involved in the pathogenesis of cell dysfunction, inflammation and organ failure during septic shock. The goal of the current study was to investigate the efficacy and safety of the clinically approved PARP inhibitor olaparib in experimental models of oxidative stress in vitro and in sepsis in vivo. In mice subjected to cecal ligation and puncture (CLP)...

    2 Ergebnisse 1