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Università della Svizzera italiana

Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Università della Svizzera italiana

Increasing cancer risk over calendar year in people with multiple sclerosis : a case–control study

Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio

In: Journal of Neurology, 2021, no. 268, p. 817–824

Background: Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods: Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS...

Università della Svizzera italiana

Dietary chloride deficiency syndrome : pathophysiology, history, and systematic literature review

Signorelli, Giulia C. ; Bianchetti, Mario G. ; Jermini, Luca M. M. ; Agostoni, Carlo ; Milani, Gregorio P. ; Simonetti, Giacomo D. ; Lava, Sebastiano A. G.

In: Nutrients, 2020, vol. 12, no. 11, p. 10 p

Metabolic alkalosis may develop as a consequence of urinary chloride (and sodium) wasting, excessive loss of salt in the sweat, or intestinal chloride wasting, among other causes. There is also a likely underrecognized association between poor salt intake and the mentioned electrolyte and acid–base abnormality. In patients with excessive loss of salt in the sweat or poor salt intake, the...

Università della Svizzera italiana

The ultrasound risk stratification systems for thyroid nodule have been evaluated against papillary carcinoma : a meta-analysis

Trimboli, Pierpaolo ; Castellana, Marco ; Piccardo, Arnoldo ; Romanelli, Francesco ; Grani, Giorgio ; Giovanella, Luca ; Durante, Cosimo

In: Reviews in endocrine and metabolic disorders, 2020, p. 8 p

Thyroid imaging reporting and data systems (TIRADS) are used to stratify the malignancy risk of thyroid nodule by ultrasound (US) examination. We conducted a meta-analysis to evaluate the pooled cancer prevalence and the relative prevalence of papillary, medullary, follicular thyroid cancer (PTC, MTC, and FTC) and other malignancies among nodules included in studies evaluating their...

Università della Svizzera italiana

Atypical bacterial pathogens and small-vessel leukocytoclastic vasculitis of the skin in children : systematic literature review

Betti, Céline ; Camozzi, Pietro ; Gennaro, Viola ; Bianchetti, Mario G. ; Scoglio, Martin ; Simonetti, Giacomo D. ; Milani, Gregorio P. ; Lava, Sebastiano A. G. ; Ferrarini, Alessandra

In: Pathogens, 2021, vol. 10, no. 1, p. 9 p

Leukocytoclastic small-vessel vasculitis of the skin (with or without systemic involvement) is often preceded by infections such as common cold, tonsillopharyngitis, or otitis media. Our purpose was to document pediatric (≤18 years) cases preceded by a symptomatic disease caused by an atypical bacterial pathogen. We performed a literature search following the Preferred Reporting of...

Università della Svizzera italiana

The human Descemet's membrane and lens capsule : protein composition and biomechanical properties

Halfter, Willi ; Moes, Suzette ; Halfter, Kathrin ; Schoenenberger, Monica S. ; Monnier, Christophe A. ; Kalita, Joanna ; Asgeirsson, Daphne ; Binggeli, Tatjana ; Jenoe, Paul ; Scholl, Hendrik P.N. ; Henrich, Paul Bernhard

In: Experimental eye research, 2020, vol. 201, no. December, p. 13 p

The Descemet's membrane (DM) and the lens capsule (LC) are two ocular basement membranes (BMs) that are essential in maintaining stability and structure of the cornea and lens. In this study, we investigated the proteomes and biomechanical properties of these two materials to uncover common and unique properties. We also screened for possible protein changes during diabetes. LC-MS/MS was used...

Università della Svizzera italiana

Primary cutaneous cryptococcosis due to Cryptococcus neoformans in an immunocompetent host treated with itraconazole and drainage : case report and review of the literature

Gaviria Morales, Elizabeth ; Guidi, Marco ; Peterka, Thomas ; Rabufetti, Andrea ; Blum, Roland ; Mainetti, Carlo

In: Case reports in dermatology, 2021, vol. 13, no. 1, p. 89-97

Cryptococcus neoformans is an opportunistic germ, usually causing infections in immunocompromised patients. The main sources of infection with C. neoformans are excrement from birds, decomposing wood, fruit, and vegetables. Primary cutaneous cryptococcosis (PCC) is a clinical entity, differing from secondary cutaneous cryptococcosis and systematic infection. We report the case of an...

Università della Svizzera italiana

Phase angle is associated with length of hospital stay, readmissions, mortality, and falls in patients hospitalized in internal-medicine wards : a retrospective cohort study

Del Giorno, Rosaria ; Quarenghi, Massimo ; Stefanelli, Kevyn ; Rigamonti, Alice ; Stanglini, Carlotta ; De Vecchi, Valentina ; Gabutti, Luca

In: Nutrition, 2021, vol. 85, no. May, p. 7 p

The aim of this study was to investigate the predictive value of bioimpedance phase angle (PA) on selected clinical outcomes in patients hospitalized in internal-medicine wards. This was a retrospective observational study of 168 patients admitted to the internalmedicine service (52.9% women, 47.1% men), with a mean (± SD) age of 73.9 ± 15.9 y. Anthropometric examination, laboratory tests,...

Università della Svizzera italiana

Embryological development of the human cranio-facial arterial system : a pictorial review

Bertulli, Lorenzo ; Robert, Thomas

In: Surgical and radiologic anatomy, 2021, p. 13 p

The embryological development of the cerebral vasculature is very complex. Historical and also more recent studies based on human embryos, comparative anatomy and cerebral angiographies allowed us to better understand this vasculature development. The knowledge and understanding of such embryological development are important for physicians interested in neurovascular pathologies. Indeed, all...

Università della Svizzera italiana

Diabetes mellitus is a risk factor for prolonged SARS-CoV-2 viral shedding in lower respiratory tract samples of critically ill patients

Buetti, Niccolò ; Trimboli, Pierpaolo ; Mazzuchelli, Timothy ; Lo Priore, Elia ; Balmelli, Carlo ; Trkola, Alexandra ; Conti, Marco ; Martinetti, Gladys ; Elzi, Luigia ; Ceschi, Alessandro ; Consonni, Vera ; Ogna, Adam ; Forni-Ogna, Valentina ; Bernasconi, Enos

In: Endocrine, 2020, p. 7 p

The length of time a critically ill coronavirus disease 2019 (COVID-19) patient remains infectious and should therefore be isolated remains unknown. This prospective study was undertaken in critically ill patients to evaluate the reliability of single negative real-time polymerase chain reaction (RT-PCR) in lower tracheal aspirates (LTA) in predicting a second negative test and to analyze...