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Université de Fribourg

Size and shape: the developmental regulation of static allometry in insects

Shingleton, Alexander W. ; Frankino, W. Anthony ; Flatt, Thomas ; Nijhout, H. Frederik ; Emlen, Douglas J.

In: BioEssays, 2007, vol. 29, no. 6, p. 536-548

Among all organisms, the size of each body part or organ scales with overall body size, a phenomenon called allometry. The study of shape and form has attracted enormous interest from biologists, but the genetic, developmental and physiological mechanisms that control allometry and the proportional growth of parts have remained elusive. Recent progress in our understanding of body‐size...

Université de Fribourg

Reproduction, fat metabolism, and life span: what is the connection?

Hansen, Malene ; Flatt, Thomas ; Aguilaniu, Hugo

In: Cell Metabolism, 2013, vol. 17, no. 1, p. 10–19

Reduced reproduction is associated with increased fat storage and prolonged life span in multiple organisms, but the underlying regulatory mechanisms remain poorly understood. Recent studies in several species provide evidence that reproduction, fat metabolism, and longevity are directly coupled. For instance, germline removal in the nematode Caenorhabditis elegans promotes longevity in part...

Université de Fribourg

A Bit of Sex Stabilizes Host+Parasite Dynamics

Flatt, Thomas ; Maire, Nicolas ; Doebeli, Michael

In: Journal of Theoretical Biology, 2001, vol. 212, no. 3, p. 345-354

To date, only a few studies have focused on the effects of sex on population dynamics. Previous models have typically found that sexual reproduction dampens population fluctuations. Although asexual and sexual reproduction are just the two endpoints along a continuum of varying rates of sex, previous work has ignored the effects of intermediate degrees of sex on population dynamics. Here we study...

Université de Fribourg

Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles

Orozco‐Terwengel, Pablo ; Kapun, Martin ; Nolte, Viola ; Kofler, Robert ; Flatt, Thomas ; Schlötterer, Christian

In: Molecular Ecology, 2012, vol. 21, no. 20, p. 4931–4941

The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent global change discussion. Here, we combined laboratory natural selection (experimental evolution) in Drosophila melanogaster with genome‐wide next generation sequencing of DNA pools (Pool‐Seq) to identify alleles that are...

Université de Fribourg

Steroid hormone regulation of C. elegans and Drosophila aging and life history

Gáliková, Martina ; Klepsatel, Peter ; Senti, Gabriele ; Flatt, Thomas

In: Experimental Gerontology, 2011, vol. 46, no. 2, p. 141–147

In the last two decades it has become clear that hormones and gene mutations in endocrine signaling pathways can exert major effects on lifespan and related life history traits in worms, flies, mice, and other organisms. While most of this research has focused on insulin/insulin-like growth factor-1 signaling, a peptide hormone pathway, recent work has shown that also lipophilic hormones play...

Université de Fribourg

Survival costs of reproduction in Drosophila

Flatt, Thomas

In: Experimental Gerontology, 2011, vol. 46, no. 5, p. 369–375

Université de Fribourg

The diversity of population responses to environmental change

Colchero, Fernando ; Jones, Owen R. ; Conde, Dalia A. ; Hodgson, David ; Zajitschek, Felix ; Schmidt, Benedikt R. ; Malo, Aurelio F. ; Alberts, Susan C. ; Becker, Peter H. ; Bouwhuis, Sandra ; Bronikowski, Anne M. ; Vleeschouwer, Kristel M. ; Delahay, Richard J. ; Dummermuth, Stefan ; Fernández‐Duque, Eduardo ; Frisenvænge, John ; Hesselsøe, Martin ; Larson, Sam ; Lemaître, Jean‐François ; McDonald, Jennifer ; Miller, David A.W. ; O'Donnell, Colin ; Packer, Craig ; Raboy, Becky E. ; Reading, Chris J. ; Wapstra, Erik ; Weimerskirch, Henri ; While, Geoffrey M. ; Baudisch, Annette ; Flatt, Thomas ; Coulson, Tim ; Gaillard, Jean‐Michel

In: Ecology Letters, 2019, p. -

The current extinction and climate change crises pressure us to predict population dynamics with ever‐greater accuracy. Although predictions rest on the well‐advanced theory of age‐structured populations, two key issues remain poorly explored. Specifically, how the age‐dependency in demographic rates and the year‐to‐year interactions between survival and fecundity affect...

Université de Fribourg

Evolution of longevity improves immunity in Drosophila

Fabian, Daniel K. ; Garschall, Kathrin ; Klepsatel, Peter ; Santos-Matos, Gonçalo ; Sucena, Élio ; Kapun, Martin ; Lemaitre, Bruno ; Schlötterer, Christian ; Arking, Robert ; Flatt, Thomas

In: Evolution Letters, 2018, vol. 2, no. 6, p. 567–579

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin signaling as a major regulator of longevity, yet whether standing variation in this pathway underlies microevolutionary changes in...

Université de Fribourg

Neuronal inputs and outputs of aging and longevity

Alcedo, Joy ; Flatt, Thomas ; Pasyukova, Elena G.

In: Frontiers in Genetics, 2013, vol. 4, p. -

An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. One of the organ systems that plays a major role in this communication and the maintenance of homeostasis is the nervous system....