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Université de Fribourg

Structure and mechanism of ATP-dependent phospholipid transporters

López-Marqués, Rosa L. ; Poulsen, Lisbeth Rosager ; Bailly, Aurélien ; Geisler, Markus ; Pomorski, Thomas Günther ; Palmgren, Michael G.

In: Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, p. -

Background: ATP-binding cassette (ABC) transporters and P4-ATPases are two large and seemingly unrelated families of primary active pumps involved in moving phospholipids from one leaflet of a biological membrane to the other.Scope of review: This review aims to identify common mechanistic features in the way phospholipid flipping is carried out by two evolutionarily unrelated families of...

Université de Fribourg

Saccharomyces cerevisiae, a model to study sterol uptake and transport in eukaryotes

Reiner, Sonja ; Micolod, Delphine ; Schneiter, Roger

In: Biochemical Society Transactions, 2005, vol. 33, no. 5, p. 1186-1188

The molecular mechanisms that govern intracellular transport of sterols in eukaryotic cells are only poorly understood. Saccharomyces cerevisiae is a facultative anaerobic organism that requires supplementation with unsaturated fatty acids and sterols to grow in the absence of oxygen, as the synthesis of these lipids requires molecular oxygen. The fact that yeast grows well under anaerobic...