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Parola chiave

Université de Fribourg

Silencing urokinase in the ventral tegmental area in vivo induces changes in cocaine-induced hyperlocomotion

Bahi, Amine ; Boyer, Frederic ; Kafri, Tal ; Dreyer, Jean-Luc

In: Journal of Neurochemistry, 2006, vol. 98, no. 5, p. 1619–1631

Serine proteases in the nervous system have functional roles in neural plasticity. Among them, urokinase-type plasminogen activator (uPA) exerts a variety of functions during development, and is involved in learning and memory. Furthermore, psychostimulants strongly induce uPA expression in the mesolimbic dopaminergic pathway. In this study, doxycycline-regulatable lentiviruses expressing either...