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IGF signaling between blastema and wound epidermis is required for fin regeneration

Chablais, Fabian ; Jaźwińska, Anna

In: Development, 2010, vol. 137, p. 871-879

In mammals, the loss of a limb is irreversible. By contrast, urodele amphibians and teleost fish are capable of nearly perfect regeneration of lost appendages. This ability depends on direct interaction between the wound epithelium and mesenchymal progenitor cells of the blastema. It has been known for decades that contact between the wound epithelium and the underlying blastema is essential for...