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Arginase‐II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l‐arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability

Xiong, Yuyan ; Yu, Yi ; Montani, Jean‐Pierre ; Yang, Zhihong ; Ming, Xiu‐Fen

In: Journal of the American Heart Association, 2013, vol. 2, no. 4, p. e000096

Background Vascular smooth muscle cell (VSMC) senescence and apoptosis are involved in atherosclerotic plaque vulnerability. Arginase‐II (Arg‐II) has been shown to promote vascular dysfunction and plaque vulnerability phenotypes in mice through uncoupling of endothelial nitric oxide synthase and activation of macrophage inflammation. The function of Arg‐II in VSMCs with respect to plaque...

Characterization of an immortalized human granulosa cell line (COV434)

Zhang, Hong ; Vollmer, Marielle ; De Geyter, Maria ; Litzistorf, Yvonne ; Ladewig, Ariane ; Dürrenberger, Markus ; Guggenheim, Richard ; Miny, Peter ; Holzgreve, Wolfgang ; De Geyter, Christian

In: Molecular Human Reproduction, 2000, vol. 6, no. 2, p. 146-153

Comparison of Fas(Apo-1/CD95)- and perforin-mediated cytotoxicity in primary T lymphocytes

Lowin, Bente ; Mattman, Chantal ; Hahne, Michael ; Tschopp, Jürg

In: International Immunology, 1996, vol. 8, no. 1, p. 57-63

Different vascular smooth muscle cell apoptosis in the human internal mammary artery and the saphenous vein: implications for bypass graft disease

Frischknecht, Karin ; Greutert, Helen ; Weisshaupt, Christian ; Kaspar, Mathias ; Yang, Zhihong ; Lüscher, Thomas F. ; Carrel, Thierry P. ; Tanner, Felix C.

In: Journal of Vascular Research, 2006, vol. 43, no. 4, p. 338-346

The remarkable patency of internal mammary artery (MA) grafts compared to saphenous vein (SV) grafts has been related to different biological properties of the two blood vessels. We examined whether proliferation and apoptosis of vascular smooth muscle cells (VSMC) from human coronary artery bypass vessels differ according to patency rates. Methods and Results: Proliferation rates to serum...

Effects of Morphine on the Differentiation and Survival of Developing Pyramidal Neurons During the Brain Growth Spurt

Massa, Horace ; Lacoh, Claudia-Marvine ; Vutskits, Laszlo

In: Toxicological Sciences, 2012, vol. 130, no. 1, p. 168-179

Effects of the Protein Kinase Inhibitor PKC412 on Gene Expression and Link to Physiological Effects in Zebrafish Danio rerio Eleuthero-Embryos

Oggier, Daniela M. ; Lenard, Anna ; Küry, Michael ; Hoeger, Birgit ; Affolter, Markus ; Fent, Karl

In: Toxicological Sciences, 2011, vol. 119, no. 1, p. 104-115

Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast

Berclaz, G. ; Altermatt, H. J. ; Rohrbach, V. ; Kieffer, I. ; Dreher, E. ; Andres, A.-C

In: Annals of Oncology, 2001, vol. 12, no. 6, p. 819-824

Gelsolin superfamily proteins: key regulators of cellular functions

Silacci, P. ; Mazzolai, L. ; Gauci, C. ; Stergiopulos, N. ; Yin, H. ; Hayoz, D.

In: Cellular and Molecular Life Sciences CMLS, 2004, vol. 61, no. 19-20, p. 2614-2623

Glucocorticoids Exert Direct Toxicity on Microvasculature: Analysis of Cell Death Mechanisms

El Zaoui, Ikram ; Behar-Cohen, Francine ; Torriglia, Alicia

In: Toxicological Sciences, 2015, vol. 143, no. 2, p. 441-453

A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions

Jud, Corinne ; Schmutz, Isabelle ; Hampp, Gabriele ; Oster, Henrik ; Albrecht, Urs

In: Biological Procedures Online, 2005, vol. 7, p. 101-116

Most behavioral experiments within circadian research are based on the analysis of locomotor activity. This paper introduces scientists to chronobiology by explaining the basic terminology used within the field. Furthermore, it aims to assist in designing, carrying out, and evaluating wheel-running experiments with rodents, particularly mice. Since light is an easily applicable stimulus that...