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Microcrystals as DAMPs and their role in joint inflammation

Busso, Nathalie ; So, Alexander

In: Rheumatology, 2012, vol. 51, no. 7, p. 1154-1160

Life-course socioeconomic status and DNA methylation of genes regulating inflammation

Stringhini, Silvia ; Polidoro, Silvia ; Sacerdote, Carlotta ; Kelly, Rachel S. ; van Veldhoven, Karin ; Agnoli, Claudia ; Grioni, Sara ; Tumino, Rosario ; Giurdanella, Maria Concetta ; Panico, Salvatore ; Mattiello, Amalia ; Palli, Domenico ; Masala, Giovanna ; Gallo, Valentina ; Castagné, Raphaële ; Paccaud, Fred ; Campanella, Gianluca ; Chadeau-Hyam, Marc ; Vineis, Paolo

In: International Journal of Epidemiology, 2015, vol. 44, no. 4, p. 1320-1330

A Comparative Study of Different In Vitro Lung Cell Culture Systems to Assess the Most Beneficial Tool for Screening the Potential Adverse Effects of Carbon Nanotubes

Clift, Martin J. D. ; Endes, Carola ; Vanhecke, Dimitri ; Wick, Peter ; Gehr, Peter ; Schins, Roel P. F. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55-64

TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease

Probert, Lesley ; Eugster, Hans-Pietro ; Akassoglou, Katerina ; Bauer, Jan ; Frei, Karl ; Lassmann, Hans ; Fontana, Adriano

In: Brain, 2000, vol. 123, no. 10, p. 2005-2019

Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin

Mueller, Nicolas J. ; Walter, Roland Β. ; Linscheid, Philippe ; Schaffner, Andreas ; Schoedon, Gabriele

In: Pteridines, 2002, vol. 13, no. 4, p. 126-132

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

Lindner, Maren ; Thümmler, Katja ; Arthur, Ariel ; Brunner, Sarah ; Elliott, Christina ; McElroy, Daniel ; Mohan, Hema ; Williams, Anna ; Edgar, Julia M. ; Schuh, Cornelia ; Stadelmann, Christine ; Barnett, Susan C. ; Lassmann, Hans ; Mücklisch, Steve ; Mudaliar, Manikhandan ; Schaeren-Wiemers, Nicole ; Meinl, Edgar ; Linington, Christopher

In: Brain, 2015, vol. 138, no. 7, p. 1875-1893

De novo expression of parvalbumin in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair

Szabolcsi, Viktória ; Celio, Marco R.

In: Glia, 2014, p. -

The calcium-binding protein parvalbumin (PV) hallmarks subpopulations of interneurons in the murine brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing for the preparation of organotypic hippocampal slice cultures (OHSCs). In OHSCs, de novo PV-expression begins shortly after the onset of...

Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney

Schreiber, Andrea ; Theilig, Franziska ; Schweda, Frank ; Höcherl, Klaus

In: Kidney International, 2012, p. -

Severe sepsis is often accompanied by acute renal failure with renal tubular dysfunction. Albuminuria is a common finding in septic patients and we studied whether it was due to an impairment of proximal tubular endocytosis of filtered albumin. We studied the regulation of megalin and cubilin, the two critical multiligand receptors responsible for albumin absorption, during severe experimental...

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

Solinas, Giovanni ; Karin, Michael

In: The FASEB Journal, 2010, p. -

Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now established that obesity results in a state of chronic low-grade inflammation thought to contribute to several metabolic disorders, including insulin resistance and pancreatic islet dysfunction. The protein kinases JNK1 and IKKβ have been found to serve as critical molecular links between obesity, metabolic...

Endothelial-specific deletion of Connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion

Chadjichristos, C.E. ; Scheckenbach, K.E.L. ; Veen, T.A.B. van ; Richani Sarieddine, M.Z. ; Wit, C. de ; Yang, Zhihong ; Roth, I. ; Bacchetta, M. ; Viswambharan, Hema ; Foglia, B. ; Dudez, T. ; Kempen, M.J.A. van ; Coenjaerts, F.E.J. ; Miquerol, L. ; Deutsch, U. ; Jongsma, H.J. ; Chanson, M. ; Kwak, B.R.

In: Circulation, 2010, vol. 121, p. 123-131

Background— Endothelial dysfunction is the initiating event of atherosclerosis. The expression of connexin40 (Cx40), an endothelial gap junction protein, is decreased during atherogenesis. In the present report, we sought to determine whether Cx40 contributes to the development of the disease.Methods and Results— Mice with ubiquitous deletion of Cx40 are hypertensive, a risk factor for...