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Université de Fribourg

Cell therapies for heart function recovery: focus on myocardial tissue engineering and nanotechnologies

Giraud, Marie Noëlle ; Guex, Anne Géraldine ; Tevaearai, Hendrik T.

In: Cardiology Research and Practice, 2012, p. -

Cell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myocardium. The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated that the efficiency of injected cells could possibly be hindered by the mechanical trauma due to the...

Université de Fribourg

Early reperfusion hemodynamics predict recovery in rat hearts: a potential approach towards evaluating cardiac grafts from non-heart-beating donors

Dornbierer, Monika ; Stadelmann, Mathieu ; Sourdon, Joevin ; Gahl, Brigitta ; Cook, Stéphane ; Carrel, Thierry P. ; Tevaearai, Hendrik T. ; Longnus, Sarah L.

In: PLoS ONE, 2012, vol. 7, no. 8, p. e43642

Aims: Cardiac grafts from non-heartbeating donors (NHBDs) could significantly increase organ availability and reduce waiting-list mortality. Reluctance to exploit hearts from NHBDs arises from obligatory delays in procurement leading to periods of warm ischemia and possible subsequent contractile dysfunction. Means for early prediction of graft suitability prior to transplantation are thus...