Université de Fribourg

Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart

Merz, Tamara ; Lukaschewski, Britta ; Wigger, Daniela ; Rupprecht, Aileen ; Wepler, Martin ; Gröger, Michael ; Hartmann, Clair ; Whiteman, Matthew ; Szabo, Csaba ; Wang, Rui ; Waller, Christiane ; Radermacher, Peter ; McCook, Oscar

In: Intensive Care Medicine Experimental, 2018, vol. 6, no. 1, p. 41

Both the hydrogen sulfide/cystathionine-γ-lyase (H2S/CSE) and oxytocin/oxytocin receptor (OT/OTR) systems have been reported to be cardioprotective. H2S can stimulate OT release, thereby affecting blood volume and pressure regulation. Systemic hyper-inflammation after blunt chest trauma is enhanced in cigarette smoke (CS)-exposed CSE−/− mice compared to wildtype (WT). CS increases...

Université de Fribourg

Cystathionine-γ-lyase expression is associated with mitochondrial respiration during sepsis-induced acute kidney injury in swine with atherosclerosis

Merz, Tamara ; Wepler, Martin ; Nußbaum, Benedikt ; Vogt, Josef ; Calzia, Enrico ; Wang, Rui ; Szabo, Csaba ; Radermacher, Peter ; McCook, Oscar

In: Intensive Care Medicine Experimental, 2018, vol. 6, no. 1, p. 43

Sepsis is associated with disturbed glucose metabolism and reduced mitochondrial activity and biogenesis, ultimately leading to multiple organ dysfunction, e.g., acute kidney injury (AKI). Cystathionine-γ-lyase (CSE), the major cardiovascular source of endogenous H2S release, is implicated in the regulation of glucose metabolism and mitochondrial activity through a PGC1α-dependent...