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Université de Fribourg

Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells

Priebe, Magdalena ; Widmer, Jérôme ; Löwa, Nina Suhartha ; Abram, Sarah-Luise ; Mottas, Inès ; Woischnig, Anne-Kathrin ; Brunetto, Priscilla S. ; Khanna, Nina ; Bourquin, Carole ; Fromm, Katharina M.

In: Nanomedicine: Nanotechnology, Biology and Medicine, 2017, vol. 13, no. 1, p. 11–22

The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding...

Université de Fribourg

Development of a polystyrene sulfonate/silver nanocomposite with self-healing properties for biomaterial applications

Girard, Jérôme ; Brunetto, Priscilla S. ; Braissant, Olivier ; Rajacic, Zarko ; Khanna, Nina ; Landmann, Regine ; Daniels, Alma U. ; Fromm, Katharina M.

In: Comptes Rendus Chimie, 2013, vol. 16, no. 6, p. 550–556

A silver polystyrene sulfonate polyelectrolyte was synthesized, showing a spontaneous reduction of silver ions to silver nanoparticles over a period of approximately 1 month. A follow-up of the nanoparticle formation via scanning electron microscopy (SEM) reveals migration of the nanoparticles towards the cracks of the polymer over time, leading to a self-healing process of the nanocomposite....

Université de Fribourg

New Antimicrobial and Biocompatible Implant Coating with Synergic Silver–Vancomycin Conjugate Action

Varisco, Massimo ; Khanna, Nina ; Brunetto, Priscilla S. ; Fromm, Katharina M.

In: ChemMedChem, 2014, vol. 9, no. 6, p. 1221-1230

Materials foreign to the body are used ever more frequently, as increasing numbers of patients require implants. As a consequence, the numbers of implant-related infections have grown as well, and with increasing resistance. Treatments often fail; thus, new antibacterial coating strategies are being developed by scientists to avoid, or at least strongly reduce, bacterial adhesion to implant...