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Characterization of renal interstitial fibroblast-specific protein1/S100A4-positive cells in healthy and inflamed rodent kidneys

Le Hir, Michel ; Hegyi, Ivan ; Cueni-Loffing, Dominique ; Loffing, Johannes ; Kaissling, Brigitte

In: Histochemistry and Cell Biology, 2005, vol. 123, no. 4-5, p. 335-346

Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys

Le Hir, Michel ; Hegyi, Ivan ; Cueni-Loffing, Dominique ; Loffing, Johannes ; Kaissling, Brigitte

In: Histochemistry and Cell Biology, 2005, vol. 123(4-5), p. 335

Fibrosis is considered as a central factor in the loss of renal function in chronic kidney diseases. The origin of fibroblasts and myofibroblasts that accumulate in the interstitium of the diseased kidney is still a matter of debate. It has been shown that accumulation of myofibroblasts in inflamed and fibrotic kidneys is associated with upregulation of fibroblast-specific protein 1 (FSP1,...