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Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC)

Yu, Zhenrong ; Serra, Andreas ; Sauter, Daniel ; Loffing, Johannes ; Ackermann, Daniel ; Frey, Felix J. ; Frey, Brigitte M. ; Vogt, Bruno

In: Nephrology Dialysis Transplantation, 2005, vol. 20, no. 9, p. 1833-1841

Dietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting system

Loffing-Cueni, Dominique ; Flores, Sandra Y. ; Sauter, Daniel ; Daidié, Dorothée ; Siegrist, Nicole ; Meneton, Pierre ; Staub, Olivier ; Loffing, Johannes

In: Journal of the American Society of Nephrology, 2006, vol. 17, p. 1264-1274

The activity of the epithelial sodium (Na⁺) channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) needs to be tightly regulated to match urinary Na⁺ excretion with dietary Na⁺ intake. The ubiquitin-protein ligase Nedd4-2, which in vitro interacts with ENaC subunits and reduces ENaC cell surface abundance and activity by ubiquitylation of the channel, may participate in...