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    Université de Fribourg

    Polyethylenimine is a strong inhibitor of human papillomavirus and cytomegalovirus infection

    Spoden, Gilles A. ; Besold, Katrin ; Krauter, Steffi ; Plachter, Bodo ; Hanik, Nils ; Kilbinger, Andreas F. M. ; Lambert, Carsten ; Florin, Luise

    In: Antimicrobial Agents and Chemotherapy, 2012, vol. 56, no. 15, p. 75-82

    Polyethylenimines are cationic polymers with potential as delivery vectors in gene therapy and with proven antimicrobial activity. However, the antiviral activity of polyethylenimines has not been addressed in detail thus far. We have studied the inhibitory effects of a linear 25-kDa polyethylenimine on infections with human papillomaviruses and human cytomegaloviruses. Preincubation of cells...