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Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

Chrast, Roman ; Scott, Hamish S. ; Madani, Rime ; Huber, Lars ; Wolfer, David P. ; Prinz, Marco ; Aguzzi, Adriano ; Lipp, Hans-Peter ; Antonarakis, Stylianos E.

In: Human Molecular Genetics, 2000, vol. 9, no. 12, p. 1853-1864

Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice

D'Adamo, Patrizia ; Welzl, Hans ; Papadimitriou, Stavros ; Raffaele di Barletta, Marina ; Tiveron, Cecilia ; Tatangelo, Laura ; Pozzi, Laura ; Chapman, Paul F. ; Knevett, Simon G. ; Ramsay, Mark F. ; Valtorta, Flavia ; Leoni, Chiara ; Menegon, Andrea ; Wolfer, David P. ; Lipp, Hans-Peter ; Toniolo, Daniela

In: Human Molecular Genetics, 2002, vol. 11, no. 21, p. 2567-2580

Eliminating the VGlut2-dependent glutamatergic transmission of parvalbumin-expressing neurons leads to deficits in locomotion and vocalization, decreased pain sensitivity, and increased dominance

Roccaro-Waldmeyer, Diana M. ; Girard, Franck ; Milani, Daniele ; Vannoni, Elisabetta ; Prétôt, Laurent ; Wolfer, David P. ; Celio, Marco R.

In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -

The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal cord. Depending on the location of these neurons, loading of their synaptic vesicles with glutamate is mediated by either of three vesicular...

Disturbed processing of contextual information in HCN3 channel deficient mice

Stieglitz, Marc S. ; Fenske, Stefanie ; Hammelmann, Verena ; Becirovic, Elvir ; Schöttle, Verena ; Delorme, James E. ; Schöll-Weidinger, Martha ; Mader, Robert ; Deussing, Jan ; Wolfer, David P. ; Seeliger, Mathias W. ; Albrecht, Urs ; Wotjak, Carsten T. ; Biel, Martin ; Michalakis, Stylianos ; Wahl-Schott, Christian

In: Frontiers in Molecular Neuroscience, 2018, vol. 10, p. -

Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) in the nervous system are implicated in a variety of neuronal functions including learning and memory, regulation of vigilance states and pain. Dysfunctions or genetic loss of these channels have been shown to cause human diseases such as epilepsy, depression, schizophrenia, and Parkinson's disease. The physiological...