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Université de Fribourg

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression

Reiner, Martin F. ; Akhmedov, Alexander ; Stivala, Simona ; Keller, Stephan ; Gaul, Daniel S. ; Bonetti, Nicole R. ; Savarese, Gianluigi ; Glanzmann, Martina ; Zhu, Cuicui ; Ruf, Wolfram ; Yang, Zhihong ; Matter, Christian M. ; Lüscher, Thomas F. ; Camici, Giovanni G. ; Beer, Juerg H.

In: Cardiovascular Research, 2017, vol. 113, no. 1, p. 61–69

The P2Y12 antagonist ticagrelor reduces mortality in patients with acute coronary syndrome (ACS), compared with clopidogrel, and the mechanisms underlying this effect are not clearly understood. Arterial thrombosis is the key event in ACS; however, direct vascular effects of either ticagrelor or clopidogrel with focus on arterial thrombosis and its key trigger tissue factor have not been...

Université de Fribourg

Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition

Gebhard, C. ; Holy, E. W. ; Camici, Giovanni G. ; Akhmedov, Alexander ; Stämpfli, S. F. ; Stähli, B. E. ; Rickenbach, B. von ; Breitenstein, A. ; Greutert, Helen ; Yang, Zhihong ; Lüscher, Thomas F. ; Tanner, Felix C.

In: Thrombosis and Haemostasis, 2012, vol. 107, no. 5, p. 803-1007

Tissue factor (TF) is the key activator of coagulation and is involved in acute coronary syndromes. Caffeine is often reported to increase cardiovascular risk; however, its effect on cardiovascular morbidity and mortality is controversial. Hence, this study was designed to investigate the impact of caffeine on endothelial TF expression in vitro . Caffeine concentration-dependently enhanced TF...

Université de Fribourg

Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy

Templin, Christian ; Meyer, Martin ; Müller, Maja Franziska ; Djonov, Valentin ; Hlushchuk, Ruslan ; Dimova, Ivanka ; Flueckiger, Stefanie ; Kronen, Peter ; Sidler, Michele ; Klein, Karina ; Nicholls, Flora ; Ghadri, Jelena-Rima ; Weber, Klaus ; Paunovic, Dragica ; Corti, Roberto ; Hoerstrup, Simon P. ; Lüscher, Thomas F. ; Landmesser, Ulf

In: European Heart Journal, 2010, vol. 31, no. 14, p. 1792-1801

Aims Coronary late stent thrombosis, a rare but devastating complication, remains an important concern in particular with the increasing use of drug-eluting stents. Notably, pathological studies have indicated that the proportion of uncovered coronary stent struts represents the best morphometric predictor of late stent thrombosis. Intracoronary optical frequency domain imaging (OFDI), a novel...

Université de Fribourg

Endothelial nitric oxide synthase gene transfer inhibits human smooth muscle cell migration via inhibition of Rho A

Largiadèr, Thomas ; Eto, Masato ; Payeli, Sravan K. ; Greutert, Helen ; Viswambharan, Hema ; Lachat, Mario ; Zünd, Gregor ; Yang, Zhihong ; Tanner, Felix C. ; Lüscher, Thomas F.

In: Journal of Cardiovascular Pharmacology, 2008, vol. 52, no. 4, p. 369-374

Smooth muscle cell (SMC) migration contributes to vascular remodeling. Nitric oxide (NO) produced via endothelial NO synthase (eNOS) inhibits SMC migration. This study analyzes signal transduction mechanisms of SMC migration targeted by NO. SMCs were cultured from human saphenous veins, and cell migration was studied using Boyden chambers. PDGF-BB (0.1 to 10 ng/ml) stimulated SMC migration in a...

Université de Fribourg

Different vascular smooth muscle cell apoptosis in the human internal mammary artery and the saphenous vein: implications for bypass graft disease

Frischknecht, Karin ; Greutert, Helen ; Weisshaupt, Christian ; Kaspar, Mathias ; Yang, Zhihong ; Lüscher, Thomas F. ; Carrel, Thierry P. ; Tanner, Felix C.

In: Journal of Vascular Research, 2006, vol. 43, no. 4, p. 338-346

The remarkable patency of internal mammary artery (MA) grafts compared to saphenous vein (SV) grafts has been related to different biological properties of the two blood vessels. We examined whether proliferation and apoptosis of vascular smooth muscle cells (VSMC) from human coronary artery bypass vessels differ according to patency rates. Methods and Results: Proliferation rates to serum...

Université de Fribourg

Dimethyl sulfoxide inhibits tissue factor expression, thrombus formation, and vascular smooth muscle cell activation: a potential treatment strategy for drug-eluting stents

Camici, Giovanni G. ; Steffel, Jan ; Akhmedov, Alexander ; Schafer, Nicola ; Baldinger, Jeannette ; Schulz, Urs ; Shojaati, Kushiar ; Matter, Christian M. ; Yang, Zhihong ; Lüscher, Thomas F. ; Tanner, Felix C.

In: Circulation, 2006, vol. 114, no. 14, p. 1512-1521

Background— Subacute stent thrombosis is a major clinical concern, and the search for new molecules to cover stents remains important. Dimethyl sulfoxide (DMSO) is used for preservation of hematopoietic progenitor cells and is infused into patients undergoing bone marrow transplantation. Despite its intravenous application, the impact of DMSO on vascular cells has not been assessed....

Université de Fribourg

Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

Kozaia, Toshiyuki ; Eto, Masato ; Yang, Zhihong ; Shimokawa, Hiroaki ; Lüscher, Thomas F.

In: Cardiovascular Research, 2005, vol. 68, p. 475 – 482

Objective: Pulsatile forces regulate vascular remodeling and trigger vascular diseases such as saphenous vein graft disease. The saphenous vein is exposed to high pressure and pulsatility only after implantation. Statins have been proved to reduce the incidence of vein graft failure. Thus, we investigated the molecular mechanisms of pulsatile stretch-induced saphenous vein smooth muscle...

Université de Fribourg

Nitric oxide synthase gene transfer inhibits biological features of bypass graft disease in the human saphenous vein

Tanner, Felix C. ; Largiadèr, Thomas ; Greutert, Helen ; Yang, Zhihong ; Lüscher, Thomas F.

In: Journal of Thoracic and Cardiovascular Surgery, 2004, vol. 127(1), p. 20

Background Bypass graft disease is related to proliferation and migration of vascular smooth muscle cells and to platelet activation with thrombus formation. Nitric oxide inhibits these biological responses; it has never been demonstrated, however, whether this occurs in intact human vascular tissue after endothelial nitric oxide synthase gene transfer. Methods We examined whether endothelial...