Université de Fribourg

Diet and longevity in the balance

Flatt, Thomas

In: Nature, 2009, vol. 462, no. 24, p. 989-990

Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acids in a diet are fine-tuned, however, lifespan can be increased without loss of fecundity — at least in fruitflies.

Université de Fribourg

Still Pondering an Age-Old Question

Flatt, Thomas ; Promislow, Daniel E. L.

In: Science, 2007, vol. 318, p. 1255-1256

A theory of trade-offs to explain why we age has spurred 50 years of interdisciplinary research in evolution and molecular genetics.

Université de Fribourg

Counting calories in Drosophila diet restriction

Min, Kyung-Jin ; Flatt, Thomas ; Kulaots, Indrek ; Tatar, Marc

In: Experimental Gerontology, 2006, vol. 42, no. 3, p. 247-251

The extension of life span by diet restriction in Drosophila has been argued to occur without limiting calories. Here we directly measure the calories assimilated by flies when maintained on full- and restricted-diets. We find that caloric intake is reduced on all diets that extend life span. Flies on low-yeast diet are long-lived and consume about half the calories of flies on high-yeast diets,...