Université de Fribourg

Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America

Fabian, Daniel K. ; Kapun, Martin ; Nolte, Viola ; Kofler, Robert ; Schmidt, Paul S. ; Schlötterer, Christian ; Flatt, Thomas

In: Molecular Ecology, 2012, vol. 21, no. 19, p. 4748–4769

Understanding the genetic underpinnings of adaptive change is a fundamental but largely unresolved problem in evolutionary biology. Drosophila melanogaster, an ancestrally tropical insect that has spread to temperate regions and become cosmopolitan, offers a powerful opportunity for identifying the molecular polymorphisms underlying clinal adaptation. Here, we use genome‐wide next‐...

Université de Fribourg

Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles

Orozco‐Terwengel, Pablo ; Kapun, Martin ; Nolte, Viola ; Kofler, Robert ; Flatt, Thomas ; Schlötterer, Christian

In: Molecular Ecology, 2012, vol. 21, no. 20, p. 4931–4941

The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent global change discussion. Here, we combined laboratory natural selection (experimental evolution) in Drosophila melanogaster with genome‐wide next generation sequencing of DNA pools (Pool‐Seq) to identify alleles that are...