Université de Fribourg

Nanostructure generation during milk digestion in presence of a cell culture model simulating the small intestine

Hempt, Claudia ; Gontsarik, Mark ; Buerki-Thurnherr, Tina ; Hirsch, Cordula ; Salentinig, Stefan

In: Journal of Colloid and Interface Science, 2020, vol. 574, p. 430–440

Hypothesis: The development of advanced oral delivery systems for bioactive compounds requires the fundamental understanding of the digestion process within the gastrointestinal tract. Towards this goal, dynamic invitro digestion models, capable of characterising the molecular as well as colloidal aspects of food, together with their biological interactions with relevant invitro cell culture...

Université de Fribourg

Single exposure to aerosolized graphene oxide and graphene nanoplatelets did not initiate an acute biological response in a 3D human lung model

Drasler, Barbara ; Kucki, Melanie ; Delhaes, Flavien ; Buerki-Thurnherr, Tina ; Vanhecke, Dimitri ; Korejwo, Daria ; Chortare, Savvina ; Barosova, Hana ; Hirsch, Cordula ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Wick, Peter

In: Carbon, 2018, vol. 137, p. 125–135

The increased mass production of graphene related materials (GRM), intended for a broad spectrum of applications, demands a thorough assessment of their potential hazard to humans and the environment. Particularly, the paramount concern has been expressed in regard to their interaction with the respiratory system in occupational exposure settings. It has been shown that GRM are easily...