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Bovine lactoferrin-induced CCL1 expression involves distinct receptors in monocyte-derived dendritic cells and their monocyte precursors

Latorre, Daniela ; Pulvirenti, Nadia ; Covino, Daniela Angela ; Varano, Barbara ; Purificato, Cristina ; Rainaldi, Gabriella ; Gauzzi, Maria Cristina ; Fantuzzi, Laura ; Conti, Lucia ; Donninelli, Gloria ; Del Cornò, Manuela ; Sabbatucci, Michela ; Gessani, Sandra ; Puddu, Patrizia

In: Toxins, 2015, vol. 7, no. 12, p. 5472-5483

Lactoferrin (LF) exhibits a wide range of immunomodulatory activities including modulation of cytokine and chemokine secretion. In this study, we demonstrate that bovine LF (bLF) up-modulates, in a concentration- and time-dependent manner, CCL1 secretion in monocytes (Mo) at the early stage of differentiation toward dendritic cells (DCs), and in fully differentiated immature Mo-derived DCs...