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Université de Fribourg

68Ga-NODAGA-RGDyK for αvβ3 integrin PET imaging : Preclinical investigation and dosimetry

Buchegger, F. ; Viertl, D. ; Baechler, Sébastien ; Dunet, V. ; Kosinski, M. ; Poitry-Yamate, C. ; Rüegg, Curzio ; Prior, J. O.

In: Nuklearmedizin, 2011, vol. 50, no. 6, p. 221-246

Aim: To visualize neovasculature and/or tumour integrin αvβ3 we selected the binding moiety Arg-Gly-Asp-D-Tyr-Lys (RGDyK) coupled to NODAGA for labeling with 68Ga. Methods: NODAGA-RGDyK (ABX) was labeled with the 68Ga eluate from the 68Ge generator IGG100 using the processor unit PharmTracer. Biodistribution was measured in female Hsd mice sacrificed 10, 30, 60 and 90 min after i.v. injection...

Université de Fribourg

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes

Xue, Gongda ; Restuccia, David F. ; Lan, Qiang ; Hynx, Debby ; Dirnhofer, Stephan ; Hess, Daniel ; Rüegg, Curzio ; Hemmings, Brian A.

In: Cancer Discovery, 2012, vol. 2, no. 3, p. 248-259

Metastatic breast tumor cells display an epithelial–mesenchymal transition (EMT) that increases cell motility, invasion, and dissemination. Although the transcription factor Twist1 has been shown to contribute to EMT and cancer metastasis, the signaling pathways regulating Twist1 activity are poorly understood. Here, we show that Twist1 is ubiquitously phosphorylated in 90% of 1,532 invasive...

Université de Fribourg

Angiogenesis and metastasis

Wyss, Christof B. ; Lorusso, Girieca ; Rüegg, Curzio

In: ESMO handbook of translational research, 2015, p. 67-80

Université de Fribourg

Angiogenic activity of breast cancer patients’ monocytes reverted by combined use of systems modeling and experimental approaches

Guex, Nicolas ; Crespo, Isaac ; Bron, Sylvian ; Ifticene-Treboux, Assia ; Faes-van’t Hull, Eveline ; Kharoubi, Solange ; Liechti, Robin ; Werffeli, Patricia ; Ibberson, Mark ; Majo, Francois ; Nicolas, Michäel ; Laurent, Julien ; Garg, Abhishek ; Lehr, Khalil Zaman,Hans-Anton ; Stevenson, Brian J. ; Rüegg, Curzio ; Coukos, George ; Delaloye, Jean-François ; Xenarios, Ioannis ; Doucey, Marie-Agnès

In: PLoS Comput Biol, 2015, vol. 11, no. 3, p. e1004050

Angiogenesis plays a key role in tumor growth and cancer progression. TIE-2-expressing monocytes (TEM) have been reported to critically account for tumor vascularization and growth in mouse tumor experimental models, but the molecular basis of their pro-angiogenic activity are largely unknown. Moreover, differences in the pro-angiogenic activity between blood circulating and tumor infiltrated TEM...

Université de Fribourg

Are integrins still practicable targets for anti-cancer therapy?

Alday-Parejo, Begoña ; Stupp, Roger ; Rüegg, Curzio

In: Cancers, 2019, vol. 11, no. 7, p. 978

Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...

Université de Fribourg

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

Secondini, Chiara ; Coquoz, Oriana ; Spagnuolo, Lorenzo ; Spinetti, Thibaud ; Peyvandi, Sanam ; Ciarloni, Laura ; Botta, Francesca ; Bourquin, Carole ; Rüegg, Curzio

In: OncoImmunology, 2017, vol. 6, no. 6, p. e1316437

Tumor angiogenesis promotes tumor growth and metastasis. Anti-angiogenic therapy in combination with chemotherapy is used for the treatment of metastatic cancers, including breast cancer but therapeutic benefits are limited. Mobilization and accumulation of myeloid-derived suppressor cells (MDSC) during tumor progression and therapy have been implicated in metastasis formation and resistance to...

Université de Fribourg

β-Arrestin1 and β-Arrestin2 are required to support the activity of the CXCL12/HMGB1 heterocomplex on CXCR4

D’Agostino, Gianluca ; Artinger, Marc ; Locati, Massimo ; Perez, Laurent ; Legler, Daniel F. ; Bianchi, Marco E. ; Rüegg, Curzio ; Thelen, Marcus ; Marchese, Adriano ; Rocchi, Marco B. L. ; Cecchinato, Valentina ; Uguccioni, Mariagrazia

In: Frontiers in Immunology, 2020, vol. 11, p. -

The chemokine receptor CXCR4 plays a fundamental role in homeostasis and pathology by orchestrating recruitment and positioning of immune cells, under the guidance of a CXCL12 gradient. The ability of chemokines to form heterocomplexes, enhancing their function, represents an additional level of regulation on their cognate receptors. In particular, the multi-faceted activity of the...

Université de Fribourg

Autologous stem cell transplantation: leukapheresis product has anti-angiogenic effects in vivo correlating with neutrophil-derived VEGFR1

Luethy, Anita ; Stenner, Frank ; Lohri, Corinne ; Muller, Christoph ; Samaras, Panagiotis ; Steiner, Rudolf ; Broek, Maries Van Den ; Mischo, Axel ; Renner, Christoph ; Knuth, Alexander ; Rüegg, Curzio ; Wenger, Roland H. ; Zweifel, Martin

In: Anticancer Research, 2011, vol. 31, no. 10, p. 3115-3124

Background: High-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT) is used for the treatment of hemato-oncologic malignancies. In this study, we measured the effect of HDC/ASCT on plasma concentrations of antiangiogenic soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and of leukapheresis products (LP) and patient serum on chick chorioallantoic...

Université de Fribourg

Baicalein inhibits acinar-to-ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment

Pu, Wei-Ling ; Luo, Ying-Ying ; Bai, Ru-Yu ; Guo, Ao-Wei ; Zhou, Kun ; Zhang, Yun-Sha ; Miao, Lin ; Rüegg, Curzio ; Hottiger, Micheal O. ; Gao, Xiu-Mei ; Sun, Li-Kang

In: Journal of Cellular Physiology, 2018, vol. 233, no. 8, p. 5747–5755

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) is associated with an increased risk of PDAC, partly due to acinar-to-ductal metaplasia (ADM). Baicalein has been shown to exert anti-inflammatory and anti-tumor effects for CP or PDAC, respectively. The aim of our study was to investigate the effect...

Université de Fribourg

Bevacizumab specifically decreases elevated levels of circulating KIT+CD11b+ cells and IL-10 in metastatic breast cancer patients

Cattin, Sarah ; Fellay, Benoît ; Pradervand, Sylvain ; Trojan, Andreas ; Ruhstaller, Thomas ; Rüegg, Curzio ; Fürstenberger, Gregor

In: Oncotarget, 2016, vol. 7, no. 10, p. 11137–11150

Whether bevacizumab exerts its anti-tumor properties through systemic effects beyond local inhibition of angiogenesis and how these effects can be monitored in patients, remain largely elusive. To address these questions, we investigated bone marrow-derived cells and cytokines in the peripheral blood of metastatic breast cancer patients undergoing therapy with...