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Università della Svizzera italiana

CXCL12α/SDF‐1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals

Negro, Samuele ; Lessi, Francesca ; Duregotti, Elisa ; Aretini, Paolo ; La Ferla, Marco ; Franceschi, Sara ; Menicagli, Marco ; Bergamin, Elisanna ; Egle, Radice ; Megighian, Aram ; Pirazzini, Marco ; Mazzanti, Chiara M. ; Rigoni, Michela ; Montecucco, Cesare

In: EMBO molecular medicine, 2017, vol. 9, no. 8, p. 1000–1010

The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter‐cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins. We report here that CXCL12α, also abbreviated as stromal‐derived factor‐1 (SDF‐1), is produced specifically by perisynaptic Schwann cells following ...