Université de Fribourg

Complete genome sequence of the clinical strain Acinetobacter baumannii R2090 Carrying the chromosomally encoded Metallo-β-Lactamase Gene blaNDM-1

Krahn, Thomas ; Wibberg, Daniel ; Maus, Irena ; Winkler, Anika ; Nordmann, Patrice ; Pühler, Alfred ; Poirel, Laurent ; Schlüter, Andreas

In: Genome Announcements, 2016, vol. 3, no. 5, p. e01008-15

Acinetobacter baumannii is an emerging human pathogen causing nosocomial and community-acquired infections. Here, we present the complete genome sequence of the clinical A. baumannii strain R2090 carrying the metallo-β-lactamase gene blaNDM-1 in its chromosome within the transposon Tn125.

Université de Fribourg

Complete genome sequencing of Acinetobacter baumannii str. K50 disclosed the large conjugative plasmid pK50a encoding the carbapenemase OXA-23 and the extended-spectrum β–lactamase GES-11

Wibberg, Daniel ; Salto, Ileana P. ; Eikmeyer, Felix G. ; Maus, Irena ; Winkler, Anika ; Nordmann, Patrice ; Pühler, Alfred ; Poirel, Laurent ; Schlüter, Andreas

In: Antimicrobial Agents and Chemotherapy, 2018, p. AAC.00212-18

Multidrug-resistant (MDR) Acinetobacter baumannii strains appeared as serious emerging nosocomial pathogens in clinical environments and especially in intensive care units (ICUs). A. baumannii strain K50 recovered from a hospitalized patient in Kuwait exhibited resistance to carbapenems, and additionally to ciprofloxacin, chloramphenicol, sulfonamides, amikacin and gentamicin. Genome...

Université de Fribourg

IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates

Schlüter, Andreas ; Nordmann, Patrice ; Bonnin, Rémy A. ; Millemann, Yves ; Eikmeyer, Felix G. ; Wibberg, Daniel ; Pühler, Alfred ; Poirel, Laurent

In: Antimicrobial Agents and Chemotherapy, 2014, p. AAC.02695–14

The whole sequence of plasmid pENVA carrying the extended-spectrum ß-lactamase gene blaCTX-M-15 was determined. It has been identified from a series of clonally-related Klebsiella pneumoniae ST274 strains recovered from companion animals. This plasmid was 253,984-bp in-size and harbored, in addition to blaCTX-M-15, a large array of genes encoding...

Université de Fribourg

Intraspecies transfer of the chromosomal Acinetobacter baumannii blaNDM-1 carbapenemase gene

Krahn, Thomas ; Wibberg, Daniel ; Maus, Irena ; Winkler, Anika ; Bontron, Séverine ; Sczyrba, Alexander ; Nordmann, Patrice ; Pühler, Alfred ; Poirel, Laurent ; Schlüter, Andreas

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 5, p. 3032–3040

The species Acinetobacter baumannii is one of the most important multidrug-resistant human pathogens. To determine its virulence and antibiotic resistance determinants, the genome of the nosocomial blaNDM-1-positive A. baumannii strain R2090 originating from Egypt was completely sequenced. Genome analysis revealed that strain R2090 is highly related to the...