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Université de Fribourg

Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate–glutamine cycle in the tree shrew visual cortex

Sonnay, Sarah ; Poirot, Jordan ; Just, Nathalie ; Clerc, Anne-Catherine ; Gruetter, Rolf ; Rainer, Gregor ; Duarte, João M. N.

In: Glia, 2018, vol. 66, no. 3, p. 477–491

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple to that of glucose utilization and of neuronal tricarboxylic acid (TCA) cycle. In this study, we tested the hypothesis that glutamatergic...

Università della Svizzera italiana

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Belaunzaran, Osiris Marroquin ; Cordero, Maria Isabel ; Setola, Veronica ; Bianchi, Siro ; Galli, Carmela ; Bouche, Nicolas ; Mlynarik, Vladimir ; Gruetter, Rolf ; Sandi, Carmen ; Bensadoun, Jean-Charles ; Molinari, Maurizio ; Aebischer, Patrick

In: Plos one, 2011, vol. 6, no. 4, p. e18268

Background: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current principal disadvantages for broadening their use in clinic. Methodology and Principal Findings: We report a novel method for the long-term ...

Université de Fribourg

Distinct contributions of Brodmann areas 1 and 2 to body ownership

Martuzzi, Roberto ; Zwaag, Wietske van der ; Dieguez, Sebastian ; Serino, Andrea ; Gruetter, Rolf ; Blanke, Olaf

In: Social Cognitive and Affective Neuroscience, 2015, vol. 10, no. 11, p. 1449-1459

Although body ownership—i.e. the feeling that our bodies belong to us—modulates activity within the primary somatosensory cortex (S1), it is still unknown whether this modulation occurs within a somatotopically defined portion of S1. We induced an illusory feeling of ownership for another person’s finger by asking participants to hold their palm against another person’s palm and to...

Consortium of Swiss Academic Libraries

Eddy current effects on a clinical 7T-68cm bore scanner

Kickler, Nils ; van der Zwaag, Wietske ; Mekle, Ralf ; Kober, Tobias ; Marques, Jose ; Krueger, Gunnar ; Gruetter, Rolf

In: Magnetic Resonance Materials in Physics, Biology and Medicine, 2010, vol. 23, no. 1, p. 39-43