In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016, vol. 1863, no. 8, p. 2054–2064
Vanilloids including capsaicin and resiniferatoxin are potent transient receptor potential vanilloid type 1 (TRPV1) agonists. TRPV1 overstimulation selectively ablates capsaicin-sensitive sensory neurons in animal models in vivo. The cytotoxic mechanisms are based on strong Na⁺ and Ca2 + influx via TRPV1 channels, which leads to mitochondrial Ca2 + accumulation and...
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In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–16
In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collecting duct cells by endocytosis causing excessive reactive oxygen species (ROS) production and a proinflammatory response. Curcumin used in the traditional medicine possesses...
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In: Journal of Biological Chemistry, 2018, vol. 293, no. 14, p. 5247–5258
Biological (or cellular) noise is the random quantitative variability of proteins and other molecules in individual, genetically identical cells. As the result of biological noise in the levels of some transcription factors that determine a cell's differentiation status, differentiated cells may dedifferentiate to a stem cell state given a sufficiently long time period. Here, to provide...
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In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015, vol. 1853, no. 3, p. 632–645
Brief changes in the cytosolic and intra-organellar Ca2 + concentration serve as specific signals for various physiological processes. In mesothelial cells lining the surface of internal organs and the walls of body cavities, a re-entry in the cell cycle (G₀–G₁ transition) evoked by serum re-administration induces long-lasting Ca2 + oscillations with a slowly...
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In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016, vol. 1863, no. 12, p. 2905–2915
Sensory neuron subpopulations as well as breast and prostate cancer cells express functional transient receptor potential vanilloid type 1 (TRPV1) ion channels; however little is known how TRPV1 activation leads to biological responses. Agonist-induced activation of TRPV1 resulted in specific spatiotemporal patterns of cytoplasmic Ca²⁺ signals in breast and prostate cancer-derived cells....
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In: In vitro cellular & developmental biology. Animal, ///-
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In: In Vitro Cellular & Developmental Biology - Animal, 2015, p. 1–8
Mesothelial cells are susceptible to 10:38 05.06.2015asbestos fiber-induced cytotoxicity and on longer time scales to transformation; the resulting mesothelioma is a highly aggressive neoplasm that is considered as incurable at the present time Zucali et al. (Cancer Treatment Reviews 37:543–558, 2011). Only few murine cell culture models of immortalized mesothelial cells and mesothelioma...
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In: Bulletin of Mathematical Biology, 2019, vol. 81, no. 5, p. 1461–1478
Here, we present a theoretical investigation with potential insights on developmental mechanisms. Three biological factors, consisting of two diffusing factors and a cell- autonomous immobile transcription factor are combined with different feedback mechanisms. This results in four different situations or fur patterns. Two of them reproduce classical Turing patterns: (1) regularly spaced...
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In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013, vol. 1833, no. 7, p. 1680–1691
Transient receptor potential vanilloid subtype 1 (TRPV1) receptor is a pain-sensing, ligand-gated, non-selective cation channel expressed in peripheral sensory neurons. Prolonged activation of TRPV1 by capsaicin leads to cell swelling and formation of membrane blebs in rat dorsal root ganglion (DRG) neurons. Similar results were obtained in NIH3T3 fibroblast cells stably expressing TRPV1. Here,...
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In: Redox Biology, 2018, vol. 14, p. 439–449
Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological properties including antipruritic, analgesic, antiseptic, anti-inflammatory and cooling effects. Here, we examined the menthol-evoked Ca2+ signals in breast and prostate cancer cell lines. The effect of menthol (50–500µM) was predicted to be mediated by the transient receptor potential ion channel...
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