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Surgery Versus Radiotherapy for Early Oropharyngeal Tumors: a Never-Ending Debate

Monnier, Yan ; Simon, Christian

In: Current Treatment Options in Oncology, 2015, vol. 16, no. 9, p. 1-13

Second primary squamous cell carcinoma arising in cutaneous flap reconstructions of two head and neck cancer patients

Monnier, Yan ; Pasche, Philippe ; Monnier, Philippe ; Andrejevic-Blant, Snezana

In: European Archives of Oto-Rhino-Laryngology, 2008, vol. 265, no. 7, p. 831-835

Radiation-induced modifications of the tumor microenvironment promote metastasis

Rüegg, Curzio ; Monnier, Yan ; Kuonen, François ; Imaizumi, Natsuko

In: Bulletin du Cancer, 2011, vol. 98, no. 6, p. 47-57

Radiotherapy is successfully used to treat cancer. Emerging evidence, however, indicates that recurrences after radiotherapy are associated with increased local invasion, metastatic spreading and poor prognosis. Radiation-induced modifications of the tumor microenvironment have been proposed to contribute to increased aggressive tumor behavior, an effect also referred to as tumor bed effect, but...

Radiotherapy suppresses angiogenesis in mice through TGF-ßRI/ALK5-dependent inhibition of endothelial cell sprouting

Imaizumi, Natsuko ; Monnier, Yan ; Hegi, Monika ; Mirimanoff, René-Olivier ; Rüegg, Curzio

In: PLoS ONE, 2010, vol. 5, no. 6, p. e11084

Background: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are naturally considered the main target of radiotherapy, emerging evidence indicates that radiotherapy also affects endothelial cell functions, and possibly also their angiogenic capacity. In spite of its clinical relevance, such putative anti-angiogenic effect of radiotherapy has not been thoroughly...