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Université de Fribourg

Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling

Asparuhova, Maria B. ; Secondini, Chiara ; Rüegg, Curzio ; Chiquet-Ehrismann, Ruth

In: Molecular Oncology, 2015, vol. 9, no. 8, p. 1510–1527

Radiotherapy is a standard treatment after conservative breast cancer surgery. However, cancers relapsing within a previously irradiated area have an increased probability to metastasize. The mechanisms responsible for this aggressiveness remain unclear. Here, we used the clinically relevant 4T1 breast cancer model mimicking aggressive local relapse after radiotherapy to identify differences...

Université de Fribourg

An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models

Fagiani, Ernesta ; Bill, Ruben ; Pisarsky, Laura ; Ivanek, Robert ; Rüegg, Curzio ; Christofori, Gerhard

In: Angiogenesis, 2015, vol. 18, no. 3, p. 327–345

Tumor growth depends on the formation of new blood vessels (tumor angiogenesis) either from preexisting vessels or by the recruitment of bone marrow-derived cells. Despite encouraging results obtained with preclinical cancer models, the therapeutic targeting of tumor angiogenesis has thus far failed to deliver an enduring clinical response in cancer patients. One major obstacle for improving...

Université de Fribourg

A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

Monaco, Alessandra ; Michelin, Olivier ; Prior, John ; Rüegg, Curzio ; Scapozza, Leonardo ; Seimbille, Yann

In: Alimentary Pharmacology & Therapeutics, 2014, vol. 39, no. 5, p. 507–517

Arginine–glycine–aspartic acid (RGD)-containing peptides have been traditionally used as PET probes to noninvasively image angiogenesis, but recently, small selective molecules for α₅β₁ integrin receptor have been developed with promising results. Sixty-one antagonists were screened, and tert-butyl...

Université de Fribourg

Inhibition of cell migration and invasion mediated by the TAT-RasGAP317–326 peptide requires the DLC1 tumor

Barras, D ; Lorusso, Girieca ; Rüegg, Curzio ; Widmann, Christian

In: Oncogene, 2014, p. -

TAT-RasGAP317–326, a peptide corresponding to the 317–326 sequence of p120 RasGAP coupled with a cell-permeable TAT-derived peptide, sensitizes the death response of various tumor cells to several anticancer treatments. We now report that this peptide is also able to increase cell adherence, prevent cell migration and inhibit matrix invasion. This is accompanied by a marked...

Université de Fribourg

Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression

Barras, David ; Lorusso, Girieca ; Lhermitte, Benoît ; Viertl, David ; Rüegg, Curzio ; Widmann, Christian

In: International Journal of Cancer, 2014, p. -

The p120 RasGAP protein negatively regulates Ras via its GAP domain. RasGAP carries several other domains that modulate several signaling molecules such as Rho. RasGAP is also a caspase-3 substrate. One of the caspase-3-generated RasGAP fragments, corresponding to amino acids 158–455 and called fragment N2, was previously reported to specifically sensitize cancer cells to death induced by...

Université de Fribourg

Synthesis and in vitro evaluation of a novel radioligand for αvβ3 integrin receptor imaging: [¹⁸F]FPPA-c(RGDfK)

Monaco, Alessandra ; Zoete, Vincent ; Alghisi, Gian Carlo ; Rüegg, Curzio ; Michelin, Olivier ; Prior, John ; Scapozza, Leonardo ; Seimbille, Yann

In: Bioorganic & Medicinal Chemistry Letters, 2013, vol. 23, no. 22, p. 6068–6072

The development of RGD-based antagonist of αvβ3 integrin receptor has enhanced the interest in PET probes to image this receptor for the early detection of cancer, to monitor the disease progression and the response to therapy. In this work, a novel prosthetic group (N-(4-fluorophenyl)pent-4-ynamide or FPPA) for the 18F-labeling of an αvβ3 selective RGD-peptide was successfully prepared....

Université de Fribourg

A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

Nichita, C. ; Ciarloni, L. ; Monnier-Benoit, S. ; Hosseinian, S. ; Dorta, G. ; Rüegg, Curzio

In: Alimentary Pharmacology & Therapeutics, 2014, vol. 39, no. 5, p. 507–517

Background: Early detection and treatment of colorectal adenomatous polyps (AP) and colorectal cancer (CRC) is associated with decreased mortality for CRC. However, accurate, non-invasive and compliant tests to screen for AP and early stages of CRC are not yet available. A blood-based screening test is highly attractive due to limited invasiveness and high acceptance rate among patients.Aim: To...

Université de Fribourg

New insights into the mechanisms of organ-specific breast cancer metastasis

Lorusso, Girieca ; Rüegg, Curzio

In: Seminars in Cancer Biology, 2012, p. -

Despite the substantial advances obtained in the treatment of localized malignancies, metastatic disease still lacks effective treatment and remains the primary cause of cancer mortality, including in breast cancer. Thus, in order to improve the survival of cancer patients it is necessary to effectively improve prevention or treatment of metastasis. To achieve this goal, complementary strategies...

Université de Fribourg

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

Garrido-Urbani, Sarah ; Jemelin, Stephane ; Deffert, Christine ; Carnesecchi, Stéphanie ; Basset, Olivier ; Szyndralewiez, Cédric ; Heitz, Freddy ; Page, Patrick ; Montet, Xavier ; Michalik, Liliane ; Arbiser, Jack ; Rüegg, Curzio ; Krause, Karl Heinz ; Imhof, Beat A.

In: PLoS ONE, 2011, vol. 6, no. 2, p. e14665

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization and activation. We show that mice deficient in NOX1, but not NOX2 or NOX4, have impaired...

Université de Fribourg

Radiotherapy suppresses angiogenesis in mice through TGF-ßRI/ALK5-dependent inhibition of endothelial cell sprouting

Imaizumi, Natsuko ; Monnier, Yan ; Hegi, Monika ; Mirimanoff, René-Olivier ; Rüegg, Curzio

In: PLoS ONE, 2010, vol. 5, no. 6, p. e11084

Background: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are naturally considered the main target of radiotherapy, emerging evidence indicates that radiotherapy also affects endothelial cell functions, and possibly also their angiogenic capacity. In spite of its clinical relevance, such putative anti-angiogenic effect of radiotherapy has not been thoroughly...