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Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells

Mulhaupt, Flore ; Matter, Christian M. ; Kwak, Brenda R. ; Pelli, Graziano ; Veillard, Niels R. ; Burger, Fabienne ; Graber, Pierre ; Lüscher, Thomas F. ; Mach, François

In: Cardiovascular Research, 2003, vol. 59, no. 3, p. 755-766

Clonal restriction and predominance of regulatory T cells in coronary thrombi of patients with acute coronary syndromes

Klingenberg, Roland ; Brokopp, Chad E. ; Grivès, Audrey ; Courtier, Anaïs ; Jaguszewski, Milosz ; Pasqual, Nicolas ; Vlaskou Badra, Eugenia ; Lewandowski, Anika ; Gaemperli, Oliver ; Hoerstrup, Simon P. ; Maier, Willibald ; Landmesser, Ulf ; Lüscher, Thomas F. ; Matter, Christian M.

In: European Heart Journal, 2015, vol. 36, no. 17, p. 1041-1048

Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice

El Kochairi, Ilhem ; Montagner, Alexandra ; Rando, Gianpaolo ; Lohmann, Christine ; Matter, Christian M. ; Wahli, Walter

In: Cardiovascular Research, 2011, vol. 91, no. 4, p. 732-741

Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study

Räber, Lorenz ; Taniwaki, Masanori ; Zaugg, Serge ; Kelbæk, Henning ; Roffi, Marco ; Holmvang, Lene ; Noble, Stephane ; Pedrazzini, Giovanni ; Moschovitis, Aris ; Lüscher, Thomas F. ; Matter, Christian M. ; Serruys, Patrick W. ; Jüni, Peter ; Garcia-Garcia, Hector M. ; Windecker, Stephan

In: European Heart Journal, 2015, vol. 36, no. 8, p. 490-500

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

Miranda, Melroy X. ; van Tits, Lambertus J. ; Lohmann, Christine ; Arsiwala, Tasneem ; Winnik, Stephan ; Tailleux, Anne ; Stein, Sokrates ; Gomes, Ana P. ; Suri, Vipin ; Ellis, James L. ; Lutz, Thomas A. ; Hottiger, Michael O. ; Sinclair, David A. ; Auwerx, Johan ; Schoonjans, Kristina ; Staels, Bart ; Lüscher, Thomas F. ; Matter, Christian M.

In: European Heart Journal, 2015, vol. 36, no. 1, p. 51-59

Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata

Brokopp, Chad E. ; Schoenauer, Roman ; Richards, Peter ; Bauer, Stefan ; Lohmann, Christine ; Emmert, Maximilian Y. ; Weber, Benedikt ; Winnik, Stephan ; Aikawa, Elena ; Graves, Kirk ; Genoni, Michele ; Vogt, Peter ; Lüscher, Thomas F. ; Renner, Christoph ; Hoerstrup, Simon P. ; Matter, Christian M.

In: European Heart Journal, 2011, vol. 32, no. 21, p. 2713-2722

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression

Reiner, Martin F. ; Akhmedov, Alexander ; Stivala, Simona ; Keller, Stephan ; Gaul, Daniel S. ; Bonetti, Nicole R. ; Savarese, Gianluigi ; Glanzmann, Martina ; Zhu, Cuicui ; Ruf, Wolfram ; Yang, Zhihong ; Matter, Christian M. ; Lüscher, Thomas F. ; Camici, Giovanni G. ; Beer, Juerg H.

In: Cardiovascular Research, 2017, vol. 113, no. 1, p. 61–69

The P2Y12 antagonist ticagrelor reduces mortality in patients with acute coronary syndrome (ACS), compared with clopidogrel, and the mechanisms underlying this effect are not clearly understood. Arterial thrombosis is the key event in ACS; however, direct vascular effects of either ticagrelor or clopidogrel with focus on arterial thrombosis and its key trigger tissue factor have not been...

Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes

Biason-Lauber, Anna ; Böni-Schnetzler, Marianne ; Hubbard, Basil P. ; Bouzakri, Karim ; Brunner, Andrea ; Cavelti-Weder, Claudia ; Keller, Cornelia ; Meyer-Böni, Monika ; Meier, Daniel T. ; Brorsson, Caroline ; Timper, Katharina ; Leibowitz, Gil ; Patrignani, Andrea ; Bruggmann, Remy ; Boily, Gino ; Zulewski, Henryk ; Geier, Andreas ; Cermak, Jennifer M. ; Elliott, Peter ; Ellis, James L. ; Westphal, Christoph ; Knobel, Urs ; Eloranta, Jyrki J. ; Kerr-Conte, Julie ; Pattou, François ; Konrad, Daniel ; Matter, Christian M. ; Fontana, Adriano ; Rogler, Gerhard ; Schlapbach, Ralph ; Regairaz, Camille ; Carballido, José M. ; Glaser, Benjamin ; McBurney, Michael W. ; Pociot, Flemming ; Sinclair, David A. ; Donath, Marc Y.

In: Cell Metabolism, 2013, vol. 17, no. 3, p. 448-455

Type 1 diabetes is caused by autoimmune-mediated β cell destruction leading to insulin deficiency. The histone deacetylase SIRT1 plays an essential role in modulating several age-related diseases. Here we describe a family carrying a mutation in the SIRT1 gene, in which all five affected members developed an autoimmune disorder: four developed type 1 diabetes, and one developed ulcerative...

Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol

Rajapakse, Angana Gupta ; Yepuri, Gautham ; Carvas, João M. ; Stein, Sokrates ; Matter, Christian M. ; Scerri, Isabelle ; Ruffieux, Jean ; Montani, Jean-Pierre ; Ming, Xiu-Fen ; Yang, Zhihong

In: PLoS ONE, 2011, vol. 6, no. 4, p. e19237

Mammalian target of rapamycin (mTOR)/S6K1 signalling emerges as a critical regulator of aging. Yet, a role of mTOR/S6K1 in aging-associated vascular endothelial dysfunction remains unknown. In this study, we investigated the role of S6K1 in aging-associated endothelial dysfunction and effects of the polyphenol resveratrol on S6K1 in aging endothelial cells. We show here that senescent endothelial...

Dimethyl sulfoxide inhibits tissue factor expression, thrombus formation, and vascular smooth muscle cell activation: a potential treatment strategy for drug-eluting stents

Camici, Giovanni G. ; Steffel, Jan ; Akhmedov, Alexander ; Schafer, Nicola ; Baldinger, Jeannette ; Schulz, Urs ; Shojaati, Kushiar ; Matter, Christian M. ; Yang, Zhihong ; Lüscher, Thomas F. ; Tanner, Felix C.

In: Circulation, 2006, vol. 114, no. 14, p. 1512-1521

Background— Subacute stent thrombosis is a major clinical concern, and the search for new molecules to cover stents remains important. Dimethyl sulfoxide (DMSO) is used for preservation of hematopoietic progenitor cells and is infused into patients undergoing bone marrow transplantation. Despite its intravenous application, the impact of DMSO on vascular cells has not been assessed....