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Université de Fribourg

Long-term effects of cannabis on brain structure

Battistella, Giovanni ; Fornari, Eleonora ; Annoni, Jean-Marie ; Chtioui, Haithem ; Dao, Kim ; Fabritius, Marie ; Favrat, Bernard ; Mall, Jean-Frédéric ; Maeder, Philippe ; Giroud, Christian

In: Neuropsychopharmacology, 2014, p. -

The dose-dependent toxicity of the main psychoactive component of cannabis in brain regions rich in cannabinoid CB1 receptors is well known in animal studies. However, research in humans does not show common findings across studies regarding the brain regions that are affected after long-term exposure to cannabis. In the present study, we investigate (using Voxel-based Morphometry) gray matter...

Université de Fribourg

Posterior SMA Syndrome following subcortical stroke: Contralateral akinesia reversed by visual feedback

Radman, Narges ; Cacioppo, Stephanie ; Spierer, Lucas ; Schmidlin, Eric ; Mayer, Eugène ; Annoni, Jean-Marie

In: Neuropsychologia, 2013, vol. 51, no. 13, p. 2605–2610

Background: The supplementary motor area (SMA) plays a key role in motor programming and production and is involved in internally-cued movements. In neurological populations, SMA syndrome following a lesion to the “SMA proper” is characterized by transient impairment of voluntary movements and motor sequences. This syndrome is assumed to follow on from an interruption of the motor...

Université de Fribourg

Principal components of functional connectivity: a new approach to study dynamic brain connectivity during rest

Leonardi, Nora ; Richiardi, Jonas ; Gschwind, Markus ; Simioni, Samanta ; Annoni, Jean-Marie ; Schluep, Myriam ; Vuilleumier, Patrik ; Ville, Dimitri Van De

In: NeuroImage, 2013, p. -

Functional connectivity (FC) as measured by correlation between fMRI BOLD time courses of distinct brain regions has revealed meaningful organization of spontaneous fluctuations in the resting brain. However, an increasing amount of evidence points to non-stationarity of FC; i.e., FC dynamically changes over time reflecting additional and rich information about brain organization, but...

Université de Fribourg

Electrical neuroimaging during auditory motion aftereffects reveals that auditory motion processing is motion sensitive but not direction selective

Magezi, David A. ; Buetler, Karin A. ; Chouiter, Leila ; Annoni, Jean-Marie ; Spierer, Lucas

In: Journal of Neurophysiology, 2013, vol. 109, no. 2, p. 321-331

Following prolonged exposure to adaptor sounds moving in a single direction, participants may perceive stationary-probe sounds as moving in the opposite direction [direction-selective auditory motion aftereffect (aMAE)] and be less sensitive to motion of any probe sounds that are actually moving (motion-sensitive aMAE). The neural mechanisms of aMAEs, and notably whether they are due to...

Université de Fribourg

A multidimensional approach to impulsivity changes in mild Alzheimer’s disease and control participants: cognitive correlates

Rochat, Lucien ; Billieux, Joël ; Juillerat Van der Linden, Anne-Claude ; Annoni, Jean-Marie ; Zekry, Dina ; Gold, Gabriel ; Linden, Martial Van der

In: Cortex, 2013, vol. 49, no. 1, p. 90–100

Introduction: Impulsive behaviors are frequently described in brain-damaged patients, including patients with Alzheimer’s disease (AD). However, few studies have examined impulsivity changes and associated cognitive impairments in AD and healthy controls. Consequently, the first aim of this study was to compare patients with mild AD and matched controls on four dimensions of impulsivity...

Université de Fribourg

Weed or wheel! FMRI, behavioural, and toxicological investigations of how cannabis smoking affects skills necessary for driving

Battistella, Giovanni ; Fornari, Eleonora ; Thomas, Aurélien ; Mall, Jean-Frédéric ; Chtioui, Haithem ; Appenzeller, Monique ; Annoni, Jean-Marie ; Favrat, Bernard ; Maeder, Philippe ; Giroud, Christian

In: PLoS ONE, 2013, vol. 8, no. 1, p. e52545

Marijuana is the most widely used illicit drug, however its effects on cognitive functions underling safe driving remain mostly unexplored. Our goal was to evaluate the impact of cannabis on the driving ability of occasional smokers, by investigating changes in the brain network involved in a tracking task. The subject characteristics, the percentage of Δ9-Tetrahydrocannabinol in the joint, and...

Université de Fribourg

Feasibility and initial efficacy of a cognitive-behavioural group programme for managing anger and aggressiveness after traumatic brain injury

Aboulafia-Brakha, T. ; Buschbeck, C. Greber ; Rochat, L. ; Annoni, Jean-Marie

In: Neuropsychological Rehabilitation: An International Journal, 2013, vol. 23, no. 2, p. 216-233

This study assesses the feasibility of a cognitive-behavioural group programme for treating anger and aggressiveness after a traumatic brain injury (TBI). Five feasibility criteria were considered: demand, implementation, practicality, acceptability and initial efficacy. A self-report questionnaire of aggressiveness (AQ-12) was administered before the intervention (T1), one week following the...

Université de Fribourg

Cognitive control of language production in bilinguals involves a partly independent process within the domain-general cognitive control network: Evidence from task-switching and electrical brain activity

Magezi, David A. ; Khateb, Asaid ; Mouthon, Michael ; Spierer, Lucas ; Annoni, Jean-Marie

In: Brain and Language, 2012, vol. 122, no. 1, p. 55–63

In highly proficient, early bilinguals, behavioural studies of the cost of switching language or task suggest qualitative differences between language control and domain-general cognitive control. By contrast, several neuroimaging studies have shown an overlap of the brain areas involved in language control and domain-general cognitive control. The current study measured both behavioural...

Université de Fribourg

Mutism and amnesia following high-Voltage electrical injury: psychogenic symptomatology triggered by organic dysfunction?

Mishra, Nishant K. ; Russmann, Heike ; Granziera, Cristina ; Maeder, Philippe ; Annoni, Jean-Marie

In: European Neurology, 2011, vol. 66, no. 4, p. 229-234

Background: Mutism and dense retrograde amnesia are found both in organic and dissociative contexts. Moreover, dissociative symptoms may be modulated by right prefrontal activity. A single case, M.R., developed left hemiparesis, mutism and retrograde amnesia after a high-voltage electric shock without evidence of lasting brain lesions. M.R. suddenly recovered from his mutism following a mild...

Université de Fribourg

Language and syntactic impairment following stroke in late bilingual aphasics

Tschirren, Muriel ; Laganaro, Marina ; Michel, Patrik ; Martory, Marie-Dominique ; Di Pietro, Marie ; Abutalebi, Jubin ; Annoni, Jean-Marie

In: Brain and Language, 2011, vol. 119, no. 3, p. 238-242

Purpose :Bilingual aphasia generally affects both languages. However, the age of acquisition of the second language (L2) seems to play a role in the anatomo-functional correlation of the syntactical/grammatical processes, thus potentially influencing the L2 syntactic impairment following a stroke. The present study aims to analyze the influence of late age of acquisition of the L2 on syntactic...