In: ACS Nano, 2014, vol. 8, no. 4, p. 3451–3460
A major contemporary concern in developing effective liposome–nanoparticle hybrids is the present inclusion size limitation of nanoparticles between vesicle bilayers, which is considered to be around 6.5 nm in diameter. In this article, we present experimental observations backed by theoretical considerations which show that greater structures can be incorporated within vesicle membranes by...
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In: IEEE Transactions on Magnetics, 2012, vol. 49, no. 1, p. 166-171
Nanocarriers, including liposomes, offer great opportunities for targeted and controlled therapy. The development in this field has led to a large panel of drug delivery systems, which can be classified into 3 different nanovector generations. However, the success of such smart materials requires the control of a large variety of properties and parameters. Unfortunately, characterization at the...
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In: ACS Nano, 2019, vol. 13, no. 7, p. 7759–7770
The long-term fate of biomedically relevant nanoparticles (NPs) at the single cell level after uptake is not fully understood yet. We report that lysosomal exocytosis of NPs is not a mechanism to reduce the particle load. Biopersistent NPs such as nonporous silica and gold remain in cells for a prolonged time. The only reduction of the intracellular NP number is observed via cell division,...
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In: RSC Advances, 2016, vol. 6, no. 8, p. 6223–6233
Nanocrystals of drug substances have important therapeutic applications, but their preparation is often difficult due to size control in bottom up approaches, or energetic milling and surface activation in top down processing. In this study, confinement within liposome nanocompartments is demonstrated to enable drug crystallization with a high aspect ratio but limited growth resulting in...
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In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55-64
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In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55-64
To determine the potential inhalatory risk posed by carbon nanotubes (CNTs), a tier-based approach beginning with an in vitro assessment must be adopted. The purpose of this study therefore was to compare 4 commonly used in vitro systems of the human lung (human blood monocyte-derived macrophages [MDM] and monocyte-derived dendritic cells [MDDC], 16HBE14o- epithelial cells, and...
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In: Scientific Reports, 2017, vol. 7, no. 1, p. 434
Determination of the cell type specific response is essential towards understanding the cellular mechanisms associated with disease states as well as assessing cell-based targeting of effective therapeutic agents. Recently, there have been increased calls for advanced in vitro multi-cellular models that provide reliable and valuable tools correlative to in vivo. In this pursuit the ability to...
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In: Biomacromolecules, 2011, vol. 12, no. 10, p. 3666–3673
Cellulose nanofibers are an attractive component of a broad range of nanomaterials. Their intriguing mechanical properties and low cost, as well as the renewable nature of cellulose make them an appealing alternative to carbon nanotubes (CNTs), which may pose a considerable health risk when inhaled. Little is known, however, concerning the potential toxicity of aerosolized cellulose nanofibers....
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In: Journal of Magnetism and Magnetic Materials, 2014, vol. 362, p. 72–79
We report on the synthesis and characterization of functional silica hybrid magnetic nanoparticles (SHMNPs). The co-condensation of 3-aminopropyltriethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) in presence of superparamagnetic iron oxide nanoparticles (SPIONs) leads to hybrid magnetic silica particles that are surface-functionalized with primary amino groups. In this work, a...
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In: Lab on a Chip, 2014, p. -
Microreactors have attracted wide attention in the nano- and biotechnology fields because they offer many advantages over standard liquid phase reactions. We report the development of a magnetic microreactor for reliable, fast and efficient surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs). A comprehensive study of the development process in terms of setup, loading...
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