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Holistic view on cell survival and dna damage: how model-based data analysis supports exploration of dynamics in biological systems

Weyland, Mathias S. ; Thumser-Henner, Pauline ; Nytko, Katarzyna J. ; Rohrer Bley, Carla ; Ulzega, Simone ; Petri-Fink, Alke ; Lattuada, Marco ; Füchslin, Rudolf M. ; Scheidegger, Stephan

In: Computational and Mathematical Methods in Medicine, 2020, vol. 2020, p. 1–11

In this work, a method is established to calibrate a model that describes the basic dynamics of DNA damage and repair. The model can be used to extend planning for radiotherapy and hyperthermia in order to include the biological effects. In contrast to “syntactic” models (e.g., describing molecular kinetics), the model used here describes radiobiological semantics, resulting in a more...