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The Mre11-Nbs1 interface is essential for viability and tumor suppression

Kim, Jun Hyun ; Grosbart, Malgorzata ; Anand, Roopesh ; Wyman, Claire ; Cejka, Petr ; Petrini, John H.J.

In: Cell reports, 2017, vol. 18, no. 2, p. 496-507

The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal levels. To delineate essential and non-essential Mre11 complex functions that are mediated by Nbs1, we used TALEN-based genome editing to derive Nbs1...