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Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells

Dimova, Ivanka ; Hlushchuk, Ruslan ; Makanya, Andrew ; Styp-Rekowska, Beata ; Ceausu, Amalia ; Flueckiger, Stefanie ; Lang, Sonja ; Semela, David ; Le Noble, Ferdinand ; Chatterjee, Suvro ; Djonov, Valentin

In: Angiogenesis, 2013, vol. 16, no. 4, p. 921-937

Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells

Dimova, Ivanka ; Hlushchuk, Ruslan ; Makanya, Andrew N. ; Styp-Rekowska, Beata ; Ceausu, Amalia ; Flueckiger, Stefanie ; Lang, Sonja ; Semela, David ; Le Noble, Ferdinand ; Chatterjee, Suvro ; Djonov, Valentin

In: Angiogenesis, 2013, p. 1-17

Notch is an intercellular signaling pathway related mainly to sprouting neo- angiogenesis. The objective of our study was to evaluate the angiogenic mechanisms involved in the vascular augmentation (sprouting/intussusception) after Notch inhibition within perfused vascular beds using the chick area vasculosa and MxCreNotch1(lox/lox) mice. In vivo monitoring combined with morphological ...

Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis

Buschmann, Ivo ; Pries, Axel ; Styp-Rekowska, Beata ; Hillmeister, Philipp ; Loufrani, Laurent ; Henrion, Daniel ; Shi, Yu ; Duelsner, Andre ; Hoefer, Imo ; Gatzke, Nora ; Wang, Haitao ; Lehmann, Kerstin ; Ulm, Lena ; Ritter, Zully ; Hauff, Peter ; Hlushchuk, Ruslan ; Djonov, Valentin ; Veen, Toon van ; Le Noble, Ferdinand

In: Development, 2010, vol. 137, p. 2187-2196

In the developing chicken embryo yolk sac vasculature, the expression of arterial identity genes requires arterial hemodynamic conditions. We hypothesize that arterial flow must provide a unique signal that is relevant for supporting arterial identity gene expression and is absent in veins. We analyzed factors related to flow, pressure and oxygenation in the chicken embryo vitelline...