Université de Fribourg

Soft, implantable bioelectronic interfaces for translational research

Schiavone, Giuseppe ; Fallegger, Florian ; Kang, Xiaoyang ; Barra, Beatrice ; Vachicouras, Nicolas ; Roussinova, Evgenia ; Furfaro, Ivan ; Jiguet, Sébastien ; Seáñez, Ismael ; Borgognon, Simon ; Rowald, Andreas ; Li, Qin ; Qin, Chuan ; Bézard, Erwan ; Bloch, Jocelyne ; Courtine, Grégoire ; Capogrosso, Marco ; Lacour, Stéphanie P.

In: Advanced Materials, 2020, vol. 32, no. 17, p. 1906512

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐ based innovation toward clinical use calls for further advances in materials, manufacturing and characterization paradigms, and design rules. Herein, a ...

Université de Fribourg

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Capogrosso, Marco ; Wagner, Fabien B. ; Gandar, Jerome ; Moraud, Eduardo Martin ; Wenger, Nikolaus ; Milekovic, Tomislav ; Shkorbatova, Polina ; Pavlova, Natalia ; Musienko, Pavel ; Bezard, Erwan ; Bloch, Jocelyne ; Courtine, Grégoire

In: Nature Protocols, 2018, vol. 13, no. 9, p. 2031–2061

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipment and surgical procedures that can be used to acquire chronic electromyographic (EMG) recordings from leg muscles and to implant targeted...

Université de Fribourg

Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury

Moraud, Eduardo Martin ; Zitzewitz, Joachim von ; Miehlbradt, Jenifer ; Wurth, Sophie ; Formento, Emanuele ; DiGiovanna, Jack ; Capogrosso, Marco ; Courtine, Grégoire ; Micera, Silvestro

In: Scientific Reports, 2018, vol. 8, no. 1, p. 76

After spinal cord injury (SCI), sensory feedback circuits critically contribute to leg motor execution. Compelled by the importance to engage these circuits during gait rehabilitation, assistive robotics and training protocols have primarily focused on guiding leg movements to reinforce sensory feedback. Despite the importance of trunk postural dynamics on gait and balance, trunk assistance...