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    Université de Fribourg

    Long-term gene silencing by RNAi

    Vastenhouw, Nadine L. ; Brunschwig, Karin ; Okihara, Kristy L. ; Müller, Fritz ; Tijsterman, Marcel ; Plasterk, Ronald H. A.

    In: Nature

    Small RNA molecules participate in a variety of activities in the cell: in a process known as RNA interference (RNAi), double-stranded RNA triggers the degradation of messenger RNA that has a matching sequence; the small RNA intermediates of this process can also modify gene expression in the nucleus¹. Here we show that a single episode of RNAi in the nematode Caenorhabditis elegans can...